60S ribosomal protein L37

Protein found in humans
RPL37
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5AJ0, 4D67, 4UJC, 4D5Y, 4UJE, 4UJD, 4V5Z

Identifiers
AliasesRPL37, L37, ribosomal protein L37
External IDsOMIM: 604181; MGI: 1914531; HomoloGene: 68110; GeneCards: RPL37; OMA:RPL37 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for RPL37
Genomic location for RPL37
Band5p13.1Start40,825,262 bp[1]
End40,835,222 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for RPL37
Genomic location for RPL37
Band15|15 A1Start5,146,127 bp[2]
End5,148,622 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • germinal epithelium

  • nipple

  • urethra

  • human penis

  • parietal pleura

  • pylorus

  • palpebral conjunctiva

  • caput epididymis

  • mucosa of sigmoid colon

  • visceral pleura
Top expressed in
  • embryo

  • embryo

  • lip

  • ventricular zone

  • dentate gyrus of hippocampal formation granule cell

  • yolk sac

  • primary visual cortex

  • superior frontal gyrus

  • granulocyte

  • muscle of thigh
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • rRNA binding
  • structural constituent of ribosome
  • RNA binding
Cellular component
  • ribosome
  • cytosol
  • intracellular anatomical structure
  • cytosolic large ribosomal subunit
  • synapse
Biological process
  • SRP-dependent cotranslational protein targeting to membrane
  • viral transcription
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • translational initiation
  • protein biosynthesis
  • rRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6167

67281

Ensembl

ENSG00000145592

ENSMUSG00000041841

UniProt

P61927

Q9D823

RefSeq (mRNA)

NM_000997

NM_026069

RefSeq (protein)

NP_000988

NP_080345

Location (UCSC)Chr 5: 40.83 – 40.84 MbChr 15: 5.15 – 5.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

60S ribosomal protein L37 is a protein that in humans is encoded by the RPL37 gene.[5][6][7]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145592 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041841 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Barnard GF, Staniunas RJ, Puder M, Steele GD Jr, Chen LB (Sep 1994). "Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain". Biochim Biophys Acta. 1218 (3): 425–8. doi:10.1016/0167-4781(94)90197-x. PMID 7545944.
  6. ^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  7. ^ a b "Entrez Gene: RPL37 ribosomal protein L37".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Su S, Bird RC (1995). "Cell cycle, differentiation and tissue-independent expression of ribosomal protein L37". Eur. J. Biochem. 232 (3): 789–97. doi:10.1111/j.1432-1033.1995.tb20874.x. PMID 7588717.
  • Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
  • Yoshihama M, Uechi T, Asakawa S, et al. (2002). "The Human Ribosomal Protein Genes: Sequencing and Comparative Analysis of 73 Genes". Genome Res. 12 (3): 379–90. doi:10.1101/gr.214202. PMC 155282. PMID 11875025.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Schwartz EI, Intine RV, Maraia RJ (2004). "CK2 Is Responsible for Phosphorylation of Human La Protein Serine-366 and Can Modulate rpL37 5′-Terminal Oligopyrimidine mRNA Metabolism". Mol. Cell. Biol. 24 (21): 9580–91. doi:10.1128/MCB.24.21.9580-9591.2004. PMC 522270. PMID 15485924.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

  • Overview of all the structural information available in the PDB for UniProt: P61927 (Human 60S ribosomal protein L37) at the PDBe-KB.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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