40S ribosomal protein S4, X isoform

Protein-coding gene in the species Homo sapiens
RPS4X
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5A2Q, 3J7R, 3J7P

Identifiers
AliasesRPS4X, CCG2, DXS306, RPS4, S4, SCAR, SCR10, ribosomal protein S4, X-linked, ribosomal protein S4 X-linked
External IDsOMIM: 312760; MGI: 98158; HomoloGene: 90857; GeneCards: RPS4X; OMA:RPS4X - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for RPS4X
Genomic location for RPS4X
BandXq13.1Start72,255,679 bp[1]
End72,277,248 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for RPS4X
Genomic location for RPS4X
BandX D|X 45.2 cMStart101,228,547 bp[2]
End101,233,000 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • germinal epithelium

  • lactiferous duct

  • tibia

  • visceral pleura

  • parietal pleura

  • corpus epididymis

  • vulva

  • epithelium of nasopharynx

  • mucosa of paranasal sinus

  • superficial temporal artery
Top expressed in
  • epiblast

  • ventricular zone

  • ganglionic eminence

  • uterus

  • zone of skin

  • spleen

  • esophagus

  • thymus

  • embryo

  • urinary bladder
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • rRNA binding
  • structural constituent of ribosome
  • protein binding
  • RNA binding
Cellular component
  • cytoplasm
  • polysome
  • cytosol
  • ribosome
  • membrane
  • focal adhesion
  • intracellular anatomical structure
  • cytosolic small ribosomal subunit
  • small ribosomal subunit
  • cytoplasmic ribonucleoprotein granule
  • extracellular exosome
  • extracellular matrix
  • nucleoplasm
  • ribonucleoprotein complex
  • synapse
Biological process
  • viral transcription
  • positive regulation of translation
  • SRP-dependent cotranslational protein targeting to membrane
  • multicellular organism development
  • positive regulation of cell population proliferation
  • translational initiation
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • rRNA processing
  • protein biosynthesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6191

20102

Ensembl

ENSG00000198034

ENSMUSG00000031320

UniProt

P62701

P62702

RefSeq (mRNA)

NM_001007

NM_009094

RefSeq (protein)

NP_000998

NP_033120

Location (UCSC)Chr X: 72.26 – 72.28 MbChr X: 101.23 – 101.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S4, X isoform is a protein that in humans is encoded by the RPS4X gene.[5][6][7]

Ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein known to be encoded by more than one gene, namely this gene and ribosomal protein S4, Y-linked (RPS4Y). The 2 isoforms encoded by these genes are not identical, but are functionally equivalent. Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been suggested that haploinsufficiency of the ribosomal protein S4 genes plays a role in Turner syndrome; however, this hypothesis is controversial. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198034 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031320 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Watanabe M, Furuno N, Goebl M, Go M, Miyauchi K, Sekiguchi T, Basilico C, Nishimito T (Apr 1992). "Molecular cloning of the human gene, CCG2, that complements the BHK-derived temperature-sensitive cell cycle mutant tsBN63: identity of CCG2 with the human X chromosomal SCAR/RPS4X gene". J Cell Sci. 100 (1): 35–43. doi:10.1242/jcs.100.1.35. PMID 1795030.
  6. ^ Zinn AR, Alagappan RK, Brown LG, Wool I, Page DC (Apr 1994). "Structure and function of ribosomal protein S4 genes on the human and mouse sex chromosomes". Mol Cell Biol. 14 (4): 2485–92. doi:10.1128/mcb.14.4.2485. PMC 358616. PMID 8139551.
  7. ^ a b "Entrez Gene: RPS4X ribosomal protein S4, X-linked".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–947. doi:10.1139/o95-101. PMID 8722009.
  • Fisher EM, Beer-Romero P, Brown LG, et al. (1991). "Homologous ribosomal protein genes on the human X and Y chromosomes: escape from X inactivation and possible implications for Turner syndrome". Cell. 63 (6): 1205–1218. doi:10.1016/0092-8674(90)90416-C. PMID 2124517. S2CID 16060228.
  • Wiles MV, Alexander CM, Goodfellow PN (1988). "Isolation of an abundantly expressed sequence from the human X chromosome by differential screening". Somat. Cell Mol. Genet. 14 (1): 31–39. doi:10.1007/BF01535047. PMID 2829364. S2CID 2698676.
  • Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Watanabe M, Zinn AR, Page DC, Nishimoto T (1993). "Functional equivalence of human X- and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome". Nat. Genet. 4 (3): 268–271. doi:10.1038/ng0793-268. PMID 8358435. S2CID 11495083.
  • Geerkens C, Just W, Held KR, Vogel W (1996). "Ullrich-Turner syndrome is not caused by haploinsufficiency of RPS4X". Hum. Genet. 97 (1): 39–44. doi:10.1007/bf00218830. PMID 8557258. S2CID 9987276.
  • Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–149. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
  • Omoe K, Endo A (1996). "Relationship between the monosomy X phenotype and Y-linked ribosomal protein S4 (Rps4) in several species of mammals: a molecular evolutionary analysis of Rps4 homologs". Genomics. 31 (1): 44–50. doi:10.1006/geno.1996.0007. PMID 8808278.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  • Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–230. doi:10.1006/geno.2000.6470. PMID 11401437.
  • Robinson RC, Turbedsky K, Kaiser DA, et al. (2001). "Crystal structure of Arp2/3 complex". Science. 294 (5547): 1679–1684. Bibcode:2001Sci...294.1679R. doi:10.1126/science.1066333. PMID 11721045. S2CID 18088124.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–396. doi:10.1093/molbev/msh027. PMID 14660691.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
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Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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