60S ribosomal protein L10

RPL10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2PA2, 5AJ0, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL10, AUTSX5, DXS648, DXS648E, L10, NOV, QM, ribosomal protein L10, MRXS35
External IDs	OMIM: 312173; MGI: 105943; HomoloGene: 130545; GeneCards: RPL10; OMA:RPL10 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 154,389,955 bp[1] End 154,409,168 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A7.3|X 37.94 cM Start 73,314,418 bp[2] End 73,316,741 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary ganglionic eminence right ovary canal of the cervix body of uterus ventricular zone right uterine tube granulocyte left uterine tube ectocervix Top expressed in epiblast lens embryo embryo esophagus ileum ganglionic eminence ventricular zone jejunum quadriceps femoris muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding RNA binding structural constituent of ribosome translation regulator activity Cellular component cytosol ribosome membrane intracellular anatomical structure endoplasmic reticulum cytosolic large ribosomal subunit nucleus smooth endoplasmic reticulum protein-containing complex Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane ribosomal large subunit assembly translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing negative regulation of transcription by RNA polymerase II negative regulation of apoptotic process regulation of translation embryonic brain development multicellular organism development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6134 110954 Ensembl ENSG00000147403 ENSMUSG00000008682 UniProt P27635 Q6ZWV3 RefSeq (mRNA) NM_006013 NM_001256577 NM_001256580 NM_001303624 NM_001303625 NM_001303626 NM_052835 RefSeq (protein) NP_001243506 NP_001243509 NP_001290553 NP_001290554 NP_001290555 NP_006004 NP_443067 Location (UCSC) Chr X: 154.39 – 154.41 Mb Chr X: 73.31 – 73.32 Mb PubMed search [3] [4]
Wikidata
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60S ribosomal protein L10 is a protein that in humans is encoded by the RPL10 gene.^[5][6]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together, these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro, studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[6]

Interactions

RPL10 has been shown to interact with YES1.^[7]

References

Further reading

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