40S ribosomal protein S15

Protein-coding gene in the species Homo sapiens
RPS15
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 3J7R, 4D61, 4UJC, 4D5L, 4UJE, 3J7P, 4V5Z, 4UJD

Identifiers
AliasesRPS15, RIG, S15, ribosomal protein S15
External IDsOMIM: 180535; MGI: 98117; HomoloGene: 110643; GeneCards: RPS15; OMA:RPS15 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for RPS15
Genomic location for RPS15
Band19p13.3Start1,438,358 bp[1]
End1,440,495 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for RPS15
Genomic location for RPS15
Band10|10 C1Start80,128,287 bp[2]
End80,129,948 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pituitary gland

  • anterior pituitary

  • right hemisphere of cerebellum

  • skin of abdomen

  • skin of leg

  • left ovary

  • right ovary

  • prostate

  • right uterine tube

  • amygdala
Top expressed in
  • efferent ductule

  • transitional epithelium of urinary bladder

  • internal carotid artery

  • abdominal wall

  • medial ganglionic eminence

  • mesenteric lymph nodes

  • maxillary prominence

  • migratory enteric neural crest cell

  • dermis

  • cervix
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • structural constituent of ribosome
  • protein binding
  • RNA binding
Cellular component
  • cytosol
  • ribosome
  • membrane
  • focal adhesion
  • cytosolic small ribosomal subunit
  • small ribosomal subunit
  • nucleus
  • nucleoplasm
Biological process
  • ribosomal small subunit export from nucleus
  • viral transcription
  • SRP-dependent cotranslational protein targeting to membrane
  • osteoblast differentiation
  • translational initiation
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • ribosomal small subunit biogenesis
  • ribosomal small subunit assembly
  • protein biosynthesis
  • rRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6209

20054

Ensembl

ENSG00000115268

ENSMUSG00000063457

UniProt

P62841

P62843

RefSeq (mRNA)

NM_001018
NM_001308226

NM_009091
NM_001310726

RefSeq (protein)

NP_001009
NP_001295155

NP_001297655
NP_033117

Location (UCSC)Chr 19: 1.44 – 1.44 MbChr 10: 80.13 – 80.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

40S ribosomal protein S15 is a protein that in humans is encoded by the RPS15 gene.[5][6]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19P family of ribosomal proteins. It is located in the cytoplasm. This gene has been found to be activated in various tumors, such as insulinomas, esophageal cancers, and colon cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115268 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063457 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Shiga K, Yamamoto H, Okamoto H (Jun 1990). "Isolation and characterization of the human homologue of rig and its pseudogenes: the functional gene has features characteristic of housekeeping genes". Proc Natl Acad Sci U S A. 87 (9): 3594–8. Bibcode:1990PNAS...87.3594S. doi:10.1073/pnas.87.9.3594. PMC 53948. PMID 2159154.
  6. ^ a b "Entrez Gene: RPS15 ribosomal protein S15".

Further reading

  • Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
  • Kitagawa M, Takasawa S, Kikuchi N, et al. (1991). "rig encodes ribosomal protein S15. The primary structure of mammalian ribosomal protein S15". FEBS Lett. 283 (2): 210–4. Bibcode:1991FEBSL.283..210K. doi:10.1016/0014-5793(91)80590-Y. PMID 2044758. S2CID 2687455.
  • Inoue C, Shiga K, Takasawa S, et al. (1987). "Evolutionary conservation of the insulinoma gene rig and its possible function". Proc. Natl. Acad. Sci. U.S.A. 84 (19): 6659–62. Bibcode:1987PNAS...84.6659I. doi:10.1073/pnas.84.19.6659. PMC 299142. PMID 2821540.
  • Marion MJ, Marion C (1988). "Ribosomal proteins S2, S6, S10, S14, S15 and S25 are localized on the surface of mammalian 40 S subunits and stabilize their conformation. A study with immobilized trypsin". FEBS Lett. 232 (2): 281–5. Bibcode:1988FEBSL.232..281M. doi:10.1016/0014-5793(88)80753-1. PMID 3378620. S2CID 44333810.
  • Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
  • Kenmochi N, Kawaguchi T, Rozen S, et al. (1998). "A map of 75 human ribosomal protein genes". Genome Res. 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human 40S ribosomal protein S15


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
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Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
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Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
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