EIF4E3

Protein-coding gene in the species Homo sapiens
EIF4E3
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4B6U, 4B6V

Identifiers
AliasesEIF4E3, eIF-4E3, eIF4E-3, eukaryotic translation initiation factor 4E family member 3
External IDsOMIM: 609896; MGI: 1914142; HomoloGene: 41652; GeneCards: EIF4E3; OMA:EIF4E3 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for EIF4E3
Genomic location for EIF4E3
Band3p13Start71,675,414 bp[1]
End71,754,773 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for EIF4E3
Genomic location for EIF4E3
Band6|6 D3Start99,625,135 bp[2]
End99,666,771 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • tibialis anterior muscle

  • deltoid muscle

  • mucosa of ileum

  • monocyte

  • myocardium of left ventricle

  • quadriceps femoris muscle

  • gastrocnemius muscle

  • vastus lateralis muscle

  • biceps brachii
Top expressed in
  • primary oocyte

  • secondary oocyte

  • zygote

  • interventricular septum

  • Rostral migratory stream

  • brown adipose tissue

  • triceps brachii muscle

  • temporal muscle

  • myocardium of ventricle

  • vastus lateralis muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • translation initiation factor activity
  • RNA binding
  • RNA 7-methylguanosine cap binding
Cellular component
  • cytoplasm
  • cytosol
  • mRNA cap binding complex
  • eukaryotic translation initiation factor 4F complex
Biological process
  • translational initiation
  • regulation of translation
  • protein biosynthesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

317649

66892

Ensembl

ENSG00000163412

ENSMUSG00000093661

UniProt

Q8N5X7

Q9DBB5

RefSeq (mRNA)

NM_001134649
NM_001134650
NM_001134651
NM_001282886
NM_173359

NM_025829

RefSeq (protein)

NP_001128121
NP_001128122
NP_001128123
NP_001269815
NP_775495

NP_080105

Location (UCSC)Chr 3: 71.68 – 71.75 MbChr 6: 99.63 – 99.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Eukaryotic translation initiation factor 4E family member 3 is a protein that in humans is encoded by the EIF4E3 gene.[5]

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163412 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000093661 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Eukaryotic translation initiation factor 4E family member 3". Retrieved 2011-09-28.
  6. ^ Joshi B, Cameron A, Jagus R (June 2004). "Characterization of mammalian eIF4E-family members". European Journal of Biochemistry. 271 (11): 2189–2203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9DBB5 (Mouse Eukaryotic translation initiation factor 4E type 3) at the PDBe-KB.
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