TSFM

Protein-coding gene in the species Homo sapiens
TSFM
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CP9

Identifiers
AliasesTSFM, EFTS, EFTSMT, Ts translation elongation factor, mitochondrial
External IDsOMIM: 604723; MGI: 1913649; HomoloGene: 4184; GeneCards: TSFM; OMA:TSFM - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for TSFM
Genomic location for TSFM
Band12q14.1Start57,782,761 bp[1]
End57,808,071 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for TSFM
Genomic location for TSFM
Band10|10 D3Start126,847,441 bp[2]
End126,866,709 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right adrenal gland

  • left adrenal gland

  • right adrenal cortex

  • left adrenal cortex

  • gonad

  • skeletal muscle tissue

  • gastrocnemius muscle

  • islet of Langerhans

  • left ventricle

  • mucosa of transverse colon
Top expressed in
  • right kidney

  • interventricular septum

  • yolk sac

  • embryo

  • embryo

  • proximal tubule

  • stomach

  • epiblast

  • endocardial cushion

  • hand
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • translation elongation factor activity
  • RNA binding
  • protein binding
Cellular component
  • mitochondrial matrix
  • intracellular anatomical structure
  • mitochondrion
  • nucleus
Biological process
  • translational elongation
  • regulation of DNA-templated transcription, elongation
  • protein biosynthesis
  • mitochondrial translational elongation
  • regulation of mitochondrial translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10102

66399

Ensembl

ENSG00000123297

ENSMUSG00000040521

UniProt

P43897

Q9CZR8

RefSeq (mRNA)

NM_005726
NM_001172695
NM_001172696
NM_001172697

NM_025537

RefSeq (protein)

NP_001166166
NP_001166167
NP_001166168
NP_005717

NP_079813

Location (UCSC)Chr 12: 57.78 – 57.81 MbChr 10: 126.85 – 126.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Elongation factor Ts, mitochondrial is a protein that in humans is encoded by the TSFM gene. It is an EF-Ts homolog.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123297 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040521 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Xin H, Woriax V, Burkhart W, Spremulli LL (Aug 1995). "Cloning and expression of mitochondrial translational elongation factor Ts from bovine and human liver". J Biol Chem. 270 (29): 17243–9. doi:10.1074/jbc.270.29.17243. PMID 7615523.
  6. ^ "Entrez Gene: TSFM Ts translation elongation factor, mitochondrial".

Further reading

  • Smeitink JA, Elpeleg O, Antonicka H, et al. (2006). "Distinct clinical phenotypes associated with a mutation in the mitochondrial translation elongation factor EFTs". Am. J. Hum. Genet. 79 (5): 869–77. doi:10.1086/508434. PMC 1698578. PMID 17033963.
  • Antonicka H, Sasarman F, Kennaway NG, Shoubridge EA (2006). "The molecular basis for tissue specificity of the oxidative phosphorylation deficiencies in patients with mutations in the mitochondrial translation factor EFG1". Hum. Mol. Genet. 15 (11): 1835–46. doi:10.1093/hmg/ddl106. PMID 16632485.
  • Maksimov VV, Arman IP, Tarantul VZ (2006). "[Identification of the proteins interacting with neuroprotective peptide humanin in a yeast two-hybrid system]". Genetika. 42 (2): 274–7. PMID 16583711.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Vernon JL, Burr PC, Wiley JE, Farwell MA (2000). "Assignment of the mitochondrial translation elongation factor Ts gene (TSFM) to human chromosome 12 bands q13→q14 by in situ hybridization and with somatic cell hybrids". Cytogenet. Cell Genet. 89 (3–4): 145–6. doi:10.1159/000015596. PMID 10965106. S2CID 201991811.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Benkowski LA, Takemoto C, Ott G, et al. (1996). "Interaction of mitochondrial elongation factors Tu.Ts with aminoacyl-tRNA". Nucleic Acids Symp. Ser. (33): 163–6. PMID 8643359.

External links

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  • 2cp9: Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts
    2cp9: Solution structure of RSGI RUH-042, a UBA domain from human mitochondrial elongation factor Ts


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