NTRK1 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/f/f5/PBB_Protein_NTRK1_image.jpg/250px-PBB_Protein_NTRK1_image.jpg) |
Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1HE7, 1SHC, 1WWA, 1WWW, 2IFG, 4AOJ, 4F0I, 4GT5, 4CRP, 4PMM, 4PMP, 4PMS, 4PMT, 4YNE, 4YPS | | |
Ідентифікатори |
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Символи | NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, neurotrophic receptor tyrosine kinase 1 |
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Зовнішні ІД | OMIM: 191315 MGI: 97383 HomoloGene: 1898 GeneCards: NTRK1 |
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Реагує на сполуку |
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entrectinib, altiratinib, milciclib[1] |
Онтологія гена |
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Молекулярна функція | • neurotrophin binding • GPI-linked ephrin receptor activity • neurotrophin receptor activity • kinase activity • ATP binding • protein kinase activity • kinase binding • transferase activity • protein homodimerization activity • GO:0001948, GO:0016582 protein binding • nucleotide binding • nerve growth factor binding • neurotrophin p75 receptor binding • protein tyrosine kinase activity • transmembrane receptor protein tyrosine kinase activity • nerve growth factor receptor activity |
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Клітинна компонента | • цитоплазма • ендосома • мембрана • late endosome membrane • cell surface • integral component of membrane • late endosome • early endosome membrane • receptor complex • клітинна мембрана • аксон • neuronal cell body • early endosome • integral component of plasma membrane • дендрит (нейробіологія) • GO:0016023 cytoplasmic vesicle • Golgi membrane • endosome membrane • GO:0009327 protein-containing complex • recycling endosome • recycling endosome membrane |
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Біологічний процес | • GO:1904089 negative regulation of neuron apoptotic process • positive regulation of protein phosphorylation • positive regulation of Ras protein signal transduction • positive regulation of programmed cell death • behavioral response to formalin induced pain • detection of temperature stimulus involved in sensory perception of pain • protein phosphorylation • циркадний ритм • positive regulation of ERK1 and ERK2 cascade • B cell differentiation • response to ethanol • іннервація • negative regulation of cell population proliferation • response to nicotine • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of synaptic transmission, glutamatergic • response to nutrient levels • learning or memory • protein autophosphorylation • negative regulation of neuron death • detection of mechanical stimulus involved in sensory perception of pain • диференціація клітин • neurotrophin TRK receptor signaling pathway • фосфорилювання • cellular response to nicotine • olfactory nerve development • response to electrical stimulus • Sertoli cell development • mechanoreceptor differentiation • нейробіологія розвитку • positive regulation of angiogenesis • positive regulation of NF-kappaB transcription factor activity • response to axon injury • sensory perception of pain • response to radiation • phosphatidylinositol-mediated signaling • sympathetic nervous system development • ephrin receptor signaling pathway • cellular response to growth factor stimulus • GO:0010260 старіння людини • response to hydrostatic pressure • response to activity • axon guidance • multicellular organism development • axonogenesis involved in innervation • positive regulation of neuron projection development • programmed cell death involved in cell development • positive regulation of synapse assembly • transmembrane receptor protein tyrosine kinase signaling pathway • microtubule-based movement • peptidyl-tyrosine phosphorylation • peptidyl-tyrosine autophosphorylation • nerve growth factor signaling pathway • cellular response to nerve growth factor stimulus • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of apoptotic process • regulation of MAPK cascade • positive regulation of MAPK cascade • cellular response to amyloid-beta |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/72/PBB_GE_NTRK1_208605_s_at_fs.png/250px-PBB_GE_NTRK1_208605_s_at_fs.png) |
Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_002529 NM_001007792 NM_001012331 |
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RefSeq (білок) | | NP_001007793 NP_001012331 NP_002520 |
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Локус (UCSC) | Хр. 1: 156.82 – 156.88 Mb | Хр. 3: 87.69 – 87.7 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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