Berbamunin sintaza
| Berbamunin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.21.3 | ||||||||
| CAS broj | 144941-42-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Berbamunin sintaza (EC 1.14.21.3, (S)-N-metilkoklaurinska oksidaza (C-O fenolno spajanje)) je enzim sa sistematskim imenom (S)-N-metilkoklaurin,NADPH:kiseonik oksidoreduktaza (C-O fenolno spajanje).[1] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (S)-N-metilkoklaurin + (R)-N-metilkoklaurin + NADPH + H+ + O2 berbamunin + NADP+ + 2H2O
Ovaj hem-tiolatni enzim (P-450) formira bisbenzilizohinolinski alkaloid berbamunin putem fenolne oksidacije N-metilkoklaurina bez inkorporacije kiseonika u produkt.
Reference
- ^ Stadler, R. & Zenk, M.H. (1993). „The purification and characterization of a unique cytochrome P-450 enzyme from Berberis stolifera plant cell cultures”. J. Biol. Chem. 268: 823—831. PMID 8380416.
Literatura
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
- Berbamunine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
- п
- р
- у
- EC1 Oksidoreduktaze /spisak
- EC2 Transferaze /spisak
- EC3 Hidrolaze /spisak
- EC4 Lijaze /spisak
- EC5 Izomeraze /spisak
- EC6 Ligaze /spisak
- B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
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