Komplementni faktor I
| Komplementni faktor I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.45 | ||||||||
| CAS broj | 80295-66-5 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Komplementni faktor I (EC 3.4.21.45, komplementno komponentni C3b inaktivator, C3b inaktivator, C3b/C4b inaktivator, C3bINA, komplementni C3b/C4b inaktivator, komplementni C4b inaktivator, konglutinogen-aktivirajući faktor C, komplementni C3b inaktivator, faktor I, komplement C4bi) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Inaktivatcija proteolitičkim razlaganjem komplementnih potkomponenti C3b, iC3b i C4b
Za odvajanje komplementne potkomponente C3b je neophodno njeno vezivanje za kofaktor faktor H ili komplementni receptor CR1.
Reference
- ↑ Nagasawa, S., Ichihara, C. and Stroud, R.M. (1980). „Cleavage of C4b by C3b inactivator: production of a nicked form from C4b, C4b', as an intermediate cleavage product of C4b by C3b inactivator”. J. Immunol. 125: 578-582. PMID 7391570.
- ↑ Crossley, L.G. (1981). „C3b inactivator and β1H”. Methods Enzymol. 80: 112-124. PMID 6210825.
- ↑ Müller-Eberhard, H.J. (1988). „Molecular organization and function of the complement system”. Annu. Rev. Biochem. 57: 321-347. PMID 3052276.
Literatura
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
Spoljašnje veze
- MeSH Complement+factor+I
- p
- r
- u
Aktivno mesto • Alosterna regulacija • Mesto vezivanja • Katalitički perfektan enzim • Koenzim • Kofaktor • Kooperativnost • EC broj • Enzimska kataliza • Inhibicija enzima • Enzimska kinetika • Lajnviver–Burk dijagram • Mihaelis–Mentenova kinetika • Spisak enzima
EC1 Oksidoreduktaze/spisak • EC2 Transferaze/spisak • EC3 Hidrolaze/spisak • EC4 Lijaze/spisak • EC5 Izomeraze/spisak • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6
