COMT |
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Estruturas disponíveis |
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PDB | Pesquisa Human UniProt: PDBe RCSB |
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Lista de códigos id do PDB |
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4XUE, 3A7E, 3BWM, 3BWY, 4PYI, 4PYJ, 4PYK, 4XUC, 4XUD |
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Identificadores |
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Nomes alternativos | COMT |
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IDs externos | OMIM: 116790 HomoloGene: 30982 GeneCards: COMT |
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Targeted by Drug |
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entacapone, tolcapona, Viroporin 3a[1] |
Ontologia genética |
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Função molecular | • transferase activity • O-methyltransferase activity • metal ion binding • GO:0001948, GO:0016582 ligação a proteínas plasmáticas • magnesium ion binding • catechol O-methyltransferase activity • GO:0102674, GO:0102675 methyltransferase activity • L-dopa O-methyltransferase activity • orcinol O-methyltransferase activity
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Componente celular | • citoplasma • integral component of membrane • corpo celular • citosol • postsynaptic membrane • membrane • membrana plasmática • Espinha dendrítica • axónio • dendrito • mitocôndria • Exossoma • intracellular membrane-bounded organelle
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Processo biológico | • multicellular organismal reproductive process • negative regulation of smooth muscle cell proliferation • GO:1904578 response to organic cyclic compound • regulation of sensory perception of pain • estrogen metabolic process • cellular response to phosphate starvation • catechol-containing compound metabolic process • female pregnancy • negative regulation of dopamine metabolic process • GO:0007571 developmental process • aprendizagem • catecholamine metabolic process • neurotransmitter catabolic process • response to lipopolysaccharide • metilação • dopamine metabolic process • response to pain • memória a curto prazo • negative regulation of renal sodium excretion • dopamine catabolic process • positive regulation of homocysteine metabolic process • catecholamine catabolic process • response to estrogen
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Sources:Amigo / QuickGO |
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Ortólogos |
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Espécie | Humano | Rato |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_000754 NM_001135161 NM_001135162 NM_007310 NM_001362828 |
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RefSeq (proteína) | |
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NP_000745 NP_001128633 NP_001128634 NP_009294 NP_001349757 |
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Localização (UCSC) | n/a | n/a |
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Pesquisa PubMed | [2] | n/a |
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Wikidata |
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