• 有機環状化合物への反応 • positive regulation of DNA repair • cellular response to organic cyclic compound • negative regulation of cell death • regulation of cysteine-type endopeptidase activity involved in apoptotic process • mammary gland epithelial cell differentiation • cellular response to DNA damage stimulus • DNA ligation • メチル化 • cellular response to ionizing radiation • cellular response to oxidative stress • response to folic acid • response to ethanol • 毒性物質への反応 • positive regulation of double-strand break repair • DNA修復 • DNAメチル化 • negative regulation of apoptotic process • DNA dealkylation involved in DNA repair
O6-メチルグアニン-DNAメチルトランスフェラーゼ(英: O6-methylguanine DNA methyltransferase、略称: MGMT)またはO6-アルキルグアニン-DNAアルキルトランスフェラーゼ(英: O6-alkylguanine DNA alkyltransferase、略称: AGT、AGAT)は、ヒトではMGMT遺伝子にコードされるタンパク質である[5][6]。MGMTはゲノムの安定性に重要であり、自然発生する変異原性DNA損傷である6-O-メチルグアニン(英語版)をグアニンに戻し、DNA修復や転写時のミスマッチやエラーを防ぐ役割を果たす。マウスでは、Mgmt遺伝子の喪失によってアルキル化試薬曝露後の発がんリスクが増大する[7]。細菌には2つのアイソザイムが存在し、Ada(英語版)、Ogt(英語版)と呼ばれている。
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関連文献
“Variability and regulation of O6-alkylguanine-DNA alkyltransferase”. Carcinogenesis24 (4): 625–35. (2003). doi:10.1093/carcin/bgg005. PMID 12727789.