HLA-E |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/7/70/HLA-E.png/250px-HLA-E.png) |
PDBに登録されている構造 |
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PDB | オルソログ検索: RCSB PDBe PDBj |
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PDBのIDコード一覧 |
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3CII, 1KPR, 1KTL, 1MHE, 2ESV, 3AM8, 3BZE, 3BZF, 3CDG |
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識別子 |
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記号 | HLA-E, EA1.2, EA2.1, HLA-6.2, MHC, QA1, major histocompatibility complex, class I, E |
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外部ID | OMIM: 143010 MGI: 95957 HomoloGene: 134018 GeneCards: HLA-E |
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遺伝子オントロジー |
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分子機能 | • beta-2-microglobulin binding • MHC class I protein binding • 受容体結合 • natural killer cell lectin-like receptor binding • peptide antigen binding • T cell receptor binding
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細胞の構成要素 | • integral component of membrane • phagocytic vesicle membrane • early endosome membrane • 膜 • MHC class Ib protein complex • ゴルジ膜 • 細胞膜 • cell surface • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • エキソソーム • recycling endosome membrane
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生物学的プロセス | • antigen processing and presentation • adaptive immune response • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • CD8-positive, alpha-beta T cell activation • interferon-gamma-mediated signaling pathway • 免疫系プロセス • antigen processing and presentation of peptide antigen via MHC class I • positive regulation of T cell mediated cytotoxicity • positive regulation of TRAIL production • positive regulation of interleukin-4 production • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • protection from natural killer cell mediated cytotoxicity • positive regulation of interleukin-13 production • type I interferon signaling pathway • 免疫応答 • regulation of natural killer cell mediated immunity • positive regulation of natural killer cell mediated immunity • regulation of immune response • positive regulation of tumor necrosis factor production • 自然免疫 • positive regulation of CD8-positive, alpha-beta T cell proliferation • antigen processing and presentation of endogenous peptide antigen via MHC class Ib
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出典:Amigo / QuickGO |
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オルソログ |
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種 | ヒト | マウス |
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Entrez | | |
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Ensembl | ENSG00000204592 ENSG00000225201 ENSG00000236632 ENSG00000230254 ENSG00000206493
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ENSG00000233904 ENSG00000229252 |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (タンパク質) | | |
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場所 (UCSC) | Chr 6: 30.49 – 30.49 Mb | Chr 6: 36.34 – 36.34 Mb |
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PubMed検索 | [3] | [4] |
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ウィキデータ |
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