Enzim pemutus rantai cabang kolesterol

Enzim pembelah rantai cabang kolesterol (bahasa Inggris: Cholesterol side-chain cleavage enzyme) atau yang lebih dikenal sebagai P450scc, dimana "scc" adalah akronim dari side-chain cleavage (pembelah rantai cabang). P450scc adalah sebuah enzim mitokondrial yang berfungsi untuk mengubah kolesterol menjadi pregnenolon. Ini adalah reaksi pertama dalam proses steroidogenesis pada seluruh jaringan mamalia yang mengkhususkan diri dalam produksi berbagai hormon steroid.^[1]

Referensi

^ Hanukoglu I (December 1992). "Steroidogenic enzymes: structure, function, and role in regulation of steroid hormone biosynthesis". The Journal of Steroid Biochemistry and Molecular Biology. 43 (8): 779–804. doi:10.1016/0960-0760(92)90307-5. PMID 22217824.

Bacaan tambahan

Helmberg A (August 1993). "Twin genes and endocrine disease: CYP21 and CYP11B genes". Acta Endocrinologica. 129 (2): 97–108. doi:10.1530/acta.0.1290097. PMID 8372604.
Papadopoulos V, Amri H, Boujrad N, Cascio C, Culty M, Garnier M, Hardwick M, Li H, Vidic B, Brown AS, Reversa JL, Bernassau JM, Drieu K (January 1997). "Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis". Steroids. 62 (1): 21–8. doi:10.1016/S0039-128X(96)00154-7. PMID 9029710.
Stocco DM (June 2000). "Intramitochondrial cholesterol transfer". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1486 (1): 184–97. doi:10.1016/S1388-1981(00)00056-1. PMID 10856721.
Kristensen VN, Kure EH, Erikstein B, Harada N, Børresen-Dale A (October 2001). "Genetic susceptibility and environmental estrogen-like compounds". Mutation Research. 482 (1–2): 77–82. doi:10.1016/S0027-5107(01)00212-3. PMID 11535251.
Strauss JF (November 2003). "Some new thoughts on the pathophysiology and genetics of polycystic ovary syndrome". Annals of the New York Academy of Sciences. 997 (1): 42–8. doi:10.1196/annals.1290.005. PMID 14644808.
Wada A, Waterman MR (November 1992). "Identification by site-directed mutagenesis of two lysine residues in cholesterol side chain cleavage cytochrome P450 that are essential for adrenodoxin binding". The Journal of Biological Chemistry. 267 (32): 22877–82. doi:10.1016/S0021-9258(18)50028-4 . PMID 1429635.
Hu MC, Guo IC, Lin JH, Chung BC (March 1991). "Regulated expression of cytochrome P-450scc (cholesterol-side-chain cleavage enzyme) in cultured cell lines detected by antibody against bacterially expressed human protein". The Biochemical Journal. 274 (Pt 3): 813–7. doi:10.1042/bj2740813. PMC 1149983 . PMID 1849407.
Sparkes RS, Klisak I, Miller WL (June 1991). "Regional mapping of genes encoding human steroidogenic enzymes: P450scc to 15q23-q24, adrenodoxin to 11q22; adrenodoxin reductase to 17q24-q25; and P450c17 to 10q24-q25". DNA and Cell Biology. 10 (5): 359–65. doi:10.1089/dna.1991.10.359. PMID 1863359.
Coghlan VM, Vickery LE (October 1991). "Site-specific mutations in human ferredoxin that affect binding to ferredoxin reductase and cytochrome P450scc". The Journal of Biological Chemistry. 266 (28): 18606–12. doi:10.1016/S0021-9258(18)55106-1 . PMID 1917982.
Matteson KJ, Chung BC, Urdea MS, Miller WL (April 1986). "Study of cholesterol side-chain cleavage (20,22 desmolase) deficiency causing congenital lipoid adrenal hyperplasia using bovine-sequence P450scc oligodeoxyribonucleotide probes". Endocrinology. 118 (4): 1296–305. doi:10.1210/endo-118-4-1296. PMID 2419119.
Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL (December 1986). "Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta". Proceedings of the National Academy of Sciences of the United States of America. 83 (23): 8962–6. doi:10.1073/pnas.83.23.8962. PMC 387054 . PMID 3024157.
Morohashi K, Sogawa K, Omura T, Fujii-Kuriyama Y (April 1987). "Gene structure of human cytochrome P-450(SCC), cholesterol desmolase". Journal of Biochemistry. 101 (4): 879–87. doi:10.1093/oxfordjournals.jbchem.a121955. PMID 3038854.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gharani N, Waterworth DM, Batty S, White D, Gilling-Smith C, Conway GS, McCarthy M, Franks S, Williamson R (March 1997). "Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism". Human Molecular Genetics. 6 (3): 397–402. doi:10.1093/hmg/6.3.397 . PMID 9147642.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hukkanen J, Mäntylä M, Kangas L, Wirta P, Hakkola J, Paakki P, Evisalmi S, Pelkonen O, Raunio H (February 1998). "Expression of cytochrome P450 genes encoding enzymes active in the metabolism of tamoxifen in human uterine endometrium". Pharmacology & Toxicology. 82 (2): 93–7. doi:10.1111/j.1600-0773.1998.tb01404.x. PMID 9498238.
Zhou Z, Shackleton CH, Pahwa S, White PC, Speiser PW (March 1998). "Prominent sex steroid metabolism in human lymphocytes". Molecular and Cellular Endocrinology. 138 (1–2): 61–9. doi:10.1016/S0303-7207(98)00052-5. PMID 9685215.