CCR5

CCR5
Proteinak kodetzen dituen genea

Identifikadoreak
Homologene: 37325 Genenames: CCR5 Ensemble: ENSG00000160791
Taxoia	Homo sapiens
Asoziazio-genetikoa	type 1 diabetes mellitus 22 ^(en) human immunodeficiency virus infectious disease ^(en)
Kokapena
Kromosoma	human chromosome 3 ^(en)

Kokapen zitogenetikoa	3p21.31
Hasiera	46411633 bp^[1]
Amaiera	46376206 bp^[2]

Transkripzioak
RNA ID	NM_001100168, NM_000579 eta NM_001394783
Ensembl	Zerrenda ENST00000292303 ENST00000445772

Sagu arrunt	Ccr5 ^(en)

Arratoi arrunt	Ccr5 ^(en)
Danio rerio	si:ch211-207g17.3 ^(en)

Danio rerio	ccr2 ^(en)

Danio rerio	ccr11.1 ^(en)
Ontologia
Kodetzen du	CCR5
Funtzio-molekularrak	Ikusi G proteina errezeptore akoplatuaren aktibitatea coreceptor activity ^(en) chemokine (C-C motif) ligand 5 binding ^(en) virus receptor activity ^(en) seinaleen transdukzio aktibitatea proteina lotura chemokine receptor activity ^(en) C-C chemokine receptor activity ^(en) actin binding ^(en) phosphatidylinositol phospholipase C activity ^(en) C-C chemokine binding ^(en) C-C chemokine receptor activity ^(en) chemokine binding ^(en) C-C chemokine binding ^(en) chemokine (C-C motif) ligand 5 binding ^(en)
Osagai-zelularra	Ikusi zitoplasma zelula-mintzaren osagai integrala endosoma mintza zelula mintz plasma-mintzaren osagai integrala external side of plasma membrane ^(en) cell surface ^(en) zitoplasma external side of plasma membrane ^(en)
Prozesu-biologikoak	Ikusi G proteina errezeptore akoplatuaren komunikazio bidea signaling ^(en) response to cholesterol ^(en) release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ^(en) positive regulation of cytosolic calcium ion concentration ^(en) cell-cell signaling ^(en) dendritic cell chemotaxis ^(en) MAPK cascade ^(en) kimiotaxia cellular defense response ^(en) cell surface receptor signaling pathway ^(en) erantzun immune inflammatory response ^(en) cellular response to lipopolysaccharide ^(en) kaltzio ioi garraioa calcium-mediated signaling ^(en) seinale transdukzio fusion of virus membrane with host plasma membrane ^(en) chemokine-mediated signaling pathway ^(en) viral process ^(en) defense response ^(en) negative regulation of macrophage apoptotic process ^(en) cytokine-mediated signaling pathway ^(en) kimiotaxia inflammatory response ^(en) erantzun immune positive regulation of cytosolic calcium ion concentration ^(en) calcium-mediated signaling ^(en) cell chemotaxis ^(en)

5 motako C-C kimiokina hartzailea, CCR5 deitua, CD4 T linfozitoen eta beste zelula immunogai batzuen gainazaleko hartzailea da. R5 motako GIB birusek kohartzaile gisa erabiltzen dute zelula ostalaria infektatzeko, ezinbestez CD4 hartzailea lotzeaz gain.^[3]. Mintzeko proteina integralen kimiokina beten hartzaile-familiaren kidea da.^[4]

Erreferentziak

↑ GRCh38: Ensembl release 89: ENSG00000160791. Ensembl.
↑ GRCh38: Ensembl release 89: ENSG00000160791. Ensembl.
↑ Euskalterm: [Hiesa Hiztegia] [2016]
↑ Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. (1996ko martxoa). «Molecular cloning and functional expression of a new human CC-chemokine receptor gene» Biochemistry 35 (11): 3362–7. doi:10.1021/bi952950g. PMID 8639485..