Zinc finger protein 516

Protein found in humans
ZNF516
Identifiers
AliasesZNF516, HsT287, zinc finger protein 516
External IDsOMIM: 615114; MGI: 2443957; HomoloGene: 37122; GeneCards: ZNF516; OMA:ZNF516 - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for ZNF516
Genomic location for ZNF516
Band18q23Start76,357,682 bp[1]
End76,495,242 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for ZNF516
Genomic location for ZNF516
Band18|18 E3Start82,928,788 bp[2]
End83,023,439 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • canal of the cervix

  • left testis

  • body of uterus

  • right testis

  • left ovary

  • right uterine tube

  • testicle

  • ectocervix

  • right ovary
Top expressed in
  • hand

  • granulocyte

  • ascending aorta

  • aortic valve

  • islet of Langerhans

  • trigeminal ganglion

  • Gonadal ridge

  • genital tubercle

  • mandibular prominence

  • abdominal wall
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • cis-regulatory region sequence-specific DNA binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
Biological process
  • multicellular organism development
  • positive regulation of transcription, DNA-templated
  • response to cold
  • adipose tissue development
  • regulation of transcription, DNA-templated
  • transcription by RNA polymerase II
  • signal transduction
  • brown fat cell differentiation
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • positive regulation of cold-induced thermogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9658

329003

Ensembl

ENSG00000101493

ENSMUSG00000058881

UniProt

Q92618

Q7TSH3

RefSeq (mRNA)

NM_014643

NM_001177464
NM_183033

RefSeq (protein)

NP_055458

NP_001170935
NP_898854

Location (UCSC)Chr 18: 76.36 – 76.5 MbChr 18: 82.93 – 83.02 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 516 is a protein that in humans is encoded by the ZNF516 gene.[5]

Function

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the Krüppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101493 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058881 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Zinc finger protein 516".

Further reading

  • Shaffer JR, Feingold E, Wang X, Lee M, Tcuenco K, Weeks DE, Weyant RJ, Crout R, McNeil DW, Marazita ML (January 2013). "GWAS of dental caries patterns in the permanent dentition". Journal of Dental Research. 92 (1): 38–44. doi:10.1177/0022034512463579. PMC 3521449. PMID 23064961.
  • Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y (April 2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex". Nature. 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765. S2CID 2670859.
  • Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  • Lee MG, Wynder C, Cooch N, Shiekhattar R (September 2005). "An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation". Nature. 437 (7057): 432–5. doi:10.1038/nature04021. PMID 16079794. S2CID 4396351.
  • Yashin AI, Wu D, Arbeev KG, Ukraintseva SV (September 2010). "Joint influence of small-effect genetic variants on human longevity". Aging. 2 (9): 612–20. doi:10.18632/aging.100191. PMC 2984609. PMID 20834067.
  • O'Brien RP, Phelan PJ, Conroy J, O'Kelly P, Green A, Keogan M, O'Neill D, Jennings S, Traynor C, Casey J, McCormack M, Conroy R, Chubb A, Ennis S, Shields DC, Cavalleri GL, Conlon PJ (2013). "A genome-wide association study of recipient genotype and medium-term kidney allograft function". Clinical Transplantation. 27 (3): 379–87. doi:10.1111/ctr.12093. PMID 23432519. S2CID 13087946.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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