ZNF224

Protein-coding gene in the species Homo sapiens
ZNF224
Available structures
PDBHuman UniProt search: PDBe RCSB
List of PDB id codes

2ELY, 2ELZ, 2EM0, 2EM6, 2EM7, 2EM8, 2EM9, 2EN1, 2EN8, 2ENA, 2ENC, 2EOQ, 2EOR, 2EQ4, 2YSP, 2YTH

Identifiers
AliasesZNF224, BMZF-2, BMZF2, KOX22, ZNF255, ZNF27, ZNF233, zinc finger protein 224
External IDsOMIM: 194555; HomoloGene: 130663; GeneCards: ZNF224; OMA:ZNF224 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ZNF224
Genomic location for ZNF224
Band19q13.31Start44,094,361 bp[1]
End44,109,886 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • rectum

  • gastric mucosa

  • right uterine tube

  • left ovary

  • spleen

  • left lobe of thyroid gland

  • right ovary

  • right lobe of thyroid gland
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nucleic acid binding
  • DNA-binding transcription factor activity
  • metal ion binding
  • DNA binding
  • DNA-binding transcription repressor activity, RNA polymerase II-specific
  • sequence-specific DNA binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleus
  • intracellular anatomical structure
  • nuclear membrane
  • transcription repressor complex
Biological process
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7767

n/a

Ensembl

ENSG00000267680

n/a

UniProt

Q9NZL3

n/a

RefSeq (mRNA)

NM_013398
NM_001321645

n/a

RefSeq (protein)

NP_001308574
NP_037530

n/a

Location (UCSC)Chr 19: 44.09 – 44.11 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Zinc finger protein 224 is a protein that in humans is encoded by the ZNF224 gene.[3]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000267680 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: ZNF224 zinc finger protein 224".

Further reading

  • Medugno L, Florio F, Cesaro E, et al. (2007). "Differential expression and cellular localization of ZNF224 and ZNF255, two isoforms of the Krüppel-like zinc-finger protein family". Gene. 403 (1–2): 125–131. doi:10.1016/j.gene.2007.07.036. PMID 17900823.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Shannon M, Hamilton AT, Gordon L, et al. (2003). "Differential Expansion of Zinc-Finger Transcription Factor Loci in Homologous Human and Mouse Gene Clusters". Genome Res. 13 (6A): 1097–1110. doi:10.1101/gr.963903. PMC 403638. PMID 12743021.
  • Medugno L, Costanzo P, Lupo A, et al. (2004). "A novel zinc finger transcriptional repressor, ZNF224, interacts with the negative regulatory element (AldA-NRE) and inhibits gene expression". FEBS Lett. 534 (1–3): 93–100. doi:10.1016/S0014-5793(02)03783-3. PMID 12527367. S2CID 3087490.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lee TH, Lwu S, Kim J, Pelletier J (2003). "Inhibition of Wilms tumor 1 transactivation by bone marrow zinc finger 2, a novel transcriptional repressor". J. Biol. Chem. 277 (47): 44826–44837. doi:10.1074/jbc.M205667200. PMID 12239212.
  • Han ZG, Zhang QH, Ye M, et al. (2000). "Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB". J. Biol. Chem. 274 (50): 35741–35748. doi:10.1074/jbc.274.50.35741. PMID 10585455.
  • Thiesen HJ (1991). "Multiple genes encoding zinc finger domains are expressed in human T cells". New Biol. 2 (4): 363–374. PMID 2288909.
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