ZNF160

Protein-coding gene in the species Homo sapiens
ZNF160
Identifiers
AliasesZNF160, F11, HKr18, HZF5, KR18, zinc finger protein 160
External IDsOMIM: 600398; HomoloGene: 131121; GeneCards: ZNF160; OMA:ZNF160 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for ZNF160
Genomic location for ZNF160
Band19q13.41-q13.42Start53,066,606 bp[1]
End53,103,434 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • renal medulla

  • endothelial cell

  • pylorus

  • nipple

  • ventral tegmental area

  • visceral pleura

  • cardia

  • sperm

  • superior surface of tongue

  • trigeminal ganglion
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • metal ion binding
  • nucleic acid binding
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • intracellular anatomical structure
  • nucleus
Biological process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
  • hemopoiesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

90338

n/a

Ensembl

ENSG00000170949

n/a

UniProt

Q9HCG1

n/a

RefSeq (mRNA)
NM_001102603
NM_033288
NM_198893
NM_001322125
NM_001322126

NM_001322128
NM_001322129
NM_001322130
NM_001322131
NM_001322132
NM_001322133
NM_001322134
NM_001322135
NM_001322136
NM_001322137
NM_001322138
NM_001322139

n/a

RefSeq (protein)
NP_001096073
NP_001309054
NP_001309055
NP_001309057
NP_001309058

NP_001309059
NP_001309060
NP_001309061
NP_001309062
NP_001309063
NP_001309064
NP_001309065
NP_001309066
NP_001309067
NP_001309068
NP_150630
NP_942596

n/a

Location (UCSC)Chr 19: 53.07 – 53.1 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Zinc finger protein 160 is a protein that, in humans, is encoded by the ZNF160 gene.[3][4][5]

The protein encoded by this gene is a Krüppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Two alternative transcripts encoding the same isoform have been described.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170949 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Halford S, Mattei MG, Daw S, Scambler PJ (Jul 1995). "A novel C2H2 zinc-finger protein gene (ZNF160) maps to human chromosome 19q13.3-q13.4". Genomics. 25 (1): 322–3. doi:10.1016/0888-7543(95)80149-G. PMID 7774943.
  4. ^ Abrink M, Aveskogh M, Hellman L (Mar 1995). "Isolation of cDNA clones for 42 different Kruppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA Cell Biol. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
  5. ^ a b "Entrez Gene: ZNF160 zinc finger protein 160".

Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Mark C, Looman C, Abrink M, Hellman L (2001). "Molecular cloning and preliminary functional analysis of two novel human KRAB zinc finger proteins, HKr18 and HKr19". DNA Cell Biol. 20 (5): 275–86. doi:10.1089/104454901750232472. PMID 11410164.
  • Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
  • Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.


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