ZMYND10

Protein-coding gene in the species Homo sapiens

ZMYND10

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2D8Q, 2DAN

Identifiers

Aliases

ZMYND10, BLU, CILD22, FLU, zinc finger MYND-type containing 10, DNAAF7

External IDs

OMIM: 607070; MGI: 2387863; HomoloGene: 9293; GeneCards: ZMYND10; OMA:ZMYND10 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p21.31	Start	50,341,110 bp^[1]
Band	3p21.31	End	50,345,732 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 F1	Start	107,424,497 bp^[2]
Band	9\|9 F1	End	107,428,518 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right uterine tube

left testis

right testis

bronchial epithelial cell

olfactory zone of nasal mucosa

testicle

mucosa of paranasal sinus

right lung

gonad

nasal epithelium

Top expressed in

spermatocyte

seminiferous tubule

morula

spermatid

right kidney

proximal tubule

human kidney

olfactory epithelium

Epithelium of choroid plexus

secondary oocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein binding metal ion binding
Cellular component	cytoplasm centriolar satellite cytoskeleton microtubule organizing center apical plasma membrane plasma membrane membrane
Biological process	outer dynein arm assembly motile cilium assembly inner dynein arm assembly positive regulation of motile cilium assembly
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


51364


114602

Ensembl


ENSG00000004838


ENSMUSG00000010044

UniProt


O75800


Q99ML0

RefSeq (mRNA)


NM_001308379 NM_015896


NM_053253 NM_001379079 NM_001379080

RefSeq (protein)


NP_001295308 NP_056980


NP_444483 NP_001366008 NP_001366009 NP_001391876

Location (UCSC)

Chr 3: 50.34 – 50.35 Mb

Chr 9: 107.42 – 107.43 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Zinc finger MYND domain-containing protein 10 is a protein that in humans is encoded by the ZMYND10 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000004838 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000010044 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Agathanggelou A, Dallol A, Zochbauer-Muller S, Morrissey C, Honorio S, Hesson L, Martinsson T, Fong KM, Kuo MJ, Yuen PW, Maher ER, Minna JD, Latif F (Mar 2003). "Epigenetic inactivation of the candidate 3p21.3 suppressor gene BLU in human cancers". Oncogene. 22 (10): 1580–8. doi:10.1038/sj.onc.1206243. PMID 12629521. S2CID 22619758.
^ "Entrez Gene: ZMYND10 zinc finger, MYND-type containing 10".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu XQ, Chen HK, Zhang XS, et al. (2003). "Alterations of BLU, a candidate tumor suppressor gene on chromosome 3p21.3, in human nasopharyngeal carcinoma". Int. J. Cancer. 106 (1): 60–5. doi:10.1002/ijc.11166. PMID 12794757. S2CID 22730979.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Qiu GH, Tan LK, Loh KS, et al. (2004). "The candidate tumor suppressor gene BLU, located at the commonly deleted region 3p21.3, is an E2F-regulated, stress-responsive gene and inactivated by both epigenetic and genetic mechanisms in nasopharyngeal carcinoma". Oncogene. 23 (27): 4793–806. doi:10.1038/sj.onc.1207632. PMID 15122337. S2CID 20374420.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Marsit CJ, Kim DH, Liu M, et al. (2005). "Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence". Int. J. Cancer. 114 (2): 219–23. doi:10.1002/ijc.20714. PMID 15540210. S2CID 6691671.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Muzny DM, Scherer SE, Kaul R, et al. (2006). "The DNA sequence, annotation and analysis of human chromosome 3". Nature. 440 (7088): 1194–8. Bibcode:2006Natur.440.1194M. doi:10.1038/nature04728. PMID 16641997.

PDB gallery

2d8q: Solution structure of the MYND domain of the human zinc finger MYND domain-containing protein 10
2dan: The solution structure of the MYND domain (LEU384-CYS430) of human Zinc finger MYND domain containing protein 10