YAF2

Protein-coding gene in the species Homo sapiens
YAF2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2D9G

Identifiers
AliasesYAF2, YY1 associated factor 2
External IDsOMIM: 607534; MGI: 1914307; HomoloGene: 136401; GeneCards: YAF2; OMA:YAF2 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for YAF2
Genomic location for YAF2
Band12q12Start42,157,104 bp[1]
End42,238,349 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for YAF2
Genomic location for YAF2
Band15|15 E3Start93,182,159 bp[2]
End93,234,816 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right auricle

  • Achilles tendon

  • gastrocnemius muscle

  • epithelium of colon

  • left ventricle

  • muscle of thigh

  • ventricular zone

  • sural nerve

  • ganglionic eminence

  • gonad
Top expressed in
  • Region I of hippocampus proper

  • barrel cortex

  • epithelium of lens

  • retinal pigment epithelium

  • substantia nigra

  • Epithelium of choroid plexus

  • iris

  • prefrontal cortex

  • blood

  • external carotid artery
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • transcription coactivator activity
  • transcription corepressor activity
Cellular component
  • nucleus
  • cytosol
  • nucleoplasm
Biological process
  • positive regulation of transcription, DNA-templated
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • negative regulation of G0 to G1 transition
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10138

67057

Ensembl

ENSG00000015153

ENSMUSG00000022634

UniProt

Q8IY57

Q99LW6

RefSeq (mRNA)
NM_001012424
NM_001190977
NM_001190979
NM_001190980
NM_005748

NM_001320080

NM_024189

RefSeq (protein)

NP_001177906
NP_001177908
NP_001177909
NP_001307009
NP_005739

NP_077151

Location (UCSC)Chr 12: 42.16 – 42.24 MbChr 15: 93.18 – 93.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene.[5][6]

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000015153 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022634 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kalenik JL, Chen D, Bradley ME, Chen SJ, Lee TC (Mar 1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1". Nucleic Acids Res. 25 (4): 843–9. doi:10.1093/nar/25.4.843. PMC 146511. PMID 9016636.
  6. ^ a b "Entrez Gene: YAF2 YY1 associated factor 2".

Further reading

  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Mädge B, Geisen C, Möröy T, Schwab M (2003). "Yaf2 inhibits Myc biological function". Cancer Lett. 193 (2): 171–6. doi:10.1016/S0304-3835(02)00696-1. PMID 12706874.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ogawa H, Ishiguro K, Gaubatz S, et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells". Science. 296 (5570): 1132–6. Bibcode:2002Sci...296.1132O. doi:10.1126/science.1069861. PMID 12004135. S2CID 34863978.
  • Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". J. Biol. Chem. 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
  • Bannasch D, Mädge B, Schwab M (2001). "Functional interaction of Yaf2 with the central region of MycN". Oncogene. 20 (41): 5913–9. doi:10.1038/sj.onc.1204747. PMID 11593398. S2CID 33486505.

External links

  • v
  • t
  • e
  • 2d9g: Solution structure of the zf-RanBP domain of YY1-associated factor 2
    2d9g: Solution structure of the zf-RanBP domain of YY1-associated factor 2


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