XTP3-transactivated gene A protein

Protein-coding gene in the species Homo sapiens
DCTPP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2A3Q, 2OIE, 2OIG, 2Q4P

Identifiers
AliasesDCTPP1, RS21C6, XTP3TPA, CDA03, XTP3-transactivated gene A protein, dCTP pyrophosphatase 1
External IDsOMIM: 615840; MGI: 1913672; HomoloGene: 11329; GeneCards: DCTPP1; OMA:DCTPP1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for DCTPP1
Genomic location for DCTPP1
Band16p11.2Start30,423,615 bp[1]
End30,430,030 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for DCTPP1
Genomic location for DCTPP1
Band7|7 F3Start126,856,131 bp[2]
End126,859,881 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • rectum

  • parotid gland

  • oocyte

  • gonad

  • mucosa of sigmoid colon

  • endothelial cell

  • nasal epithelium

  • hair follicle

  • pancreatic ductal cell
Top expressed in
  • embryo

  • embryo

  • epiblast

  • yolk sac

  • otic placode

  • primitive streak

  • somite

  • ventricular zone

  • medial ganglionic eminence

  • morula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • pyrophosphatase activity
  • protein binding
  • hydrolase activity
  • magnesium ion binding
  • metal ion binding
  • identical protein binding
  • pyrimidine deoxyribonucleotide binding
  • dCTP diphosphatase activity
  • nucleoside-triphosphate diphosphatase activity
Cellular component
  • cytoplasm
  • cytosol
  • nucleus
  • mitochondrion
Biological process
  • protein homotetramerization
  • dCTP catabolic process
  • nucleoside triphosphate catabolic process
  • DNA protection
  • dTTP catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

79077

66422

Ensembl

ENSG00000179958

ENSMUSG00000042462

UniProt

Q9H773

Q9QY93

RefSeq (mRNA)

NM_024096

NM_023203

RefSeq (protein)

NP_077001

NP_075692

Location (UCSC)Chr 16: 30.42 – 30.43 MbChr 7: 126.86 – 126.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

dCTP pyrophosphatase 1 is an enzyme that in humans is encoded by the DCTPP1 gene.[5][6]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179958 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042462 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Moroz OV, Murzin AG, Makarova KS, Koonin EV, Wilson KS, Galperin MY (Mar 2005). "Dimeric dUTPases, HisE, and MazG belong to a new superfamily of all-alpha NTP pyrophosphohydrolases with potential "house-cleaning" functions". J Mol Biol. 347 (2): 243–55. doi:10.1016/j.jmb.2005.01.030. PMID 15740738.
  6. ^ "Entrez Gene: XTP3TPA XTP3-transactivated protein A".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • v
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  • 2oie: Crystal structure of RS21-C6 core segment RSCUT
    2oie: Crystal structure of RS21-C6 core segment RSCUT
  • 2oig: Crystal structure of RS21-C6 core segment and dm5CTP complex
    2oig: Crystal structure of RS21-C6 core segment and dm5CTP complex
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