TSTA3

Protein-coding gene in the species Homo sapiens
GFUS
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4B8W, 4BKP, 4E5Y, 4B8Z, 4BL5

Identifiers
AliasesGFUS, FX, P35B, SDR4E1, tissue specific transplantation antigen P35B, TSTA3, GDP-L-fucose synthase
External IDsOMIM: 137020; MGI: 98857; HomoloGene: 2484; GeneCards: GFUS; OMA:GFUS - orthologs
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for GFUS
Genomic location for GFUS
Band8q24.3Start143,612,618 bp[1]
End143,618,048 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for GFUS
Genomic location for GFUS
Band15 D3|15 35.1 cMStart75,796,525 bp[2]
End75,801,681 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • body of stomach

  • skin of abdomen

  • mucosa of esophagus

  • duodenum

  • skin of leg

  • salivary gland

  • minor salivary glands

  • body of pancreas

  • mucosa of transverse colon

  • fundus
Top expressed in
  • Paneth cell

  • crypt of lieberkuhn of small intestine

  • pyloric antrum

  • large intestine

  • colon

  • lacrimal gland

  • motor neuron

  • duodenum

  • seminal vesicula

  • facial motor nucleus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • electron transfer activity
  • GDP-4-dehydro-D-rhamnose reductase activity
  • catalytic activity
  • oxidoreductase activity
  • GDP-L-fucose synthase activity
  • isomerase activity
  • identical protein binding
  • GDP-mannose 3,5-epimerase activity
Cellular component
  • extracellular exosome
  • cytosol
  • cytoplasm
Biological process
  • GDP-mannose metabolic process
  • leukocyte cell-cell adhesion
  • metabolism
  • cytolysis
  • 'de novo' GDP-L-fucose biosynthetic process
  • nucleotide-sugar biosynthetic process
  • electron transport chain
  • T cell mediated cytotoxicity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

7264

22122

Ensembl

ENSG00000104522
ENSG00000278243

ENSMUSG00000022570

UniProt

Q13630

P23591

RefSeq (mRNA)

NM_003313
NM_001317783

NM_031201
NM_001357005

RefSeq (protein)

NP_001304712
NP_003304

NP_112478
NP_001343934

Location (UCSC)Chr 8: 143.61 – 143.62 MbChr 15: 75.8 – 75.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GDP-L-fucose synthetase is an enzyme that in humans is encoded by the TSTA3 gene.[5][6][7][8]

Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II.[8]

References

  1. ^ a b c ENSG00000278243 GRCh38: Ensembl release 89: ENSG00000104522, ENSG00000278243 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022570 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Camardella L, Carratore V, Ciardiello MA, Damonte G, Benatti U, De Flora A (Feb 1995). "Primary structure of human erythrocyte nicotinamide adenine dinucleotide phosphate (NADP[H])-binding protein FX: identification with the mouse tum- transplantation antigen P35B". Blood. 85 (1): 264–7. doi:10.1182/blood.V85.1.264.bloodjournal851264. PMID 7803801.
  6. ^ Dyson PJ, de Smet C, Knight AM, Simon-Chazottes D, Guenet JL, Boon T (May 1992). "Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198". Immunogenetics. 35 (5): 316–23. doi:10.1007/bf00189894. PMID 1348494. S2CID 9048773.
  7. ^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
  8. ^ a b "Entrez Gene: TSTA3 tissue specific transplantation antigen P35B".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
  • Sullivan FX, Kumar R, Kriz R, et al. (1998). "Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro". J. Biol. Chem. 273 (14): 8193–202. doi:10.1074/jbc.273.14.8193. PMID 9525924.
  • Tonetti M, Sturla L, Bisso A, et al. (1996). "Synthesis of GDP-L-fucose by the human FX protein". J. Biol. Chem. 271 (44): 27274–9. doi:10.1074/jbc.271.44.27274. PMID 8910301.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human GDP-L-fucose synthase


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