TMCO1

Protein-coding gene in the species Homo sapiens
TMCO1
Identifiers
AliasesTMCO1, HP10122, PCIA3, PNAS-136, TMCC4, transmembrane and coiled-coil domains 1
External IDsOMIM: 614123; MGI: 1921173; HomoloGene: 10384; GeneCards: TMCO1; OMA:TMCO1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TMCO1
Genomic location for TMCO1
Band1q24.1Start165,724,293 bp[1]
End165,827,755 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for TMCO1
Genomic location for TMCO1
Band1|1 H2.3Start167,135,947 bp[2]
End167,161,547 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • Epithelium of choroid plexus

  • rectum

  • islet of Langerhans

  • jejunal mucosa

  • gallbladder

  • mucosa of colon

  • mucosa of transverse colon

  • bronchial epithelial cell

  • mucosa of sigmoid colon
Top expressed in
  • right kidney

  • seminal vesicula

  • molar

  • parotid gland

  • left lung lobe

  • spermatocyte

  • decidua

  • submandibular gland

  • atrioventricular valve

  • human kidney
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • calcium channel activity
Cellular component
  • membrane
  • endoplasmic reticulum membrane
  • Golgi membrane
  • Golgi apparatus
  • integral component of membrane
  • endoplasmic reticulum
  • integral component of endoplasmic reticulum membrane
Biological process
  • calcium ion transport
  • ER overload response
  • ion transport
  • calcium ion transmembrane transport
  • endoplasmic reticulum calcium ion homeostasis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54499

68944

Ensembl

ENSG00000143183

ENSMUSG00000052428

UniProt

Q9UM00

Q921L3

RefSeq (mRNA)

NM_001256164
NM_001256165
NM_019026
NM_001366129

NM_001039483
NM_026881

RefSeq (protein)

NP_001243093
NP_001243094
NP_061899

NP_001034572

Location (UCSC)Chr 1: 165.72 – 165.83 MbChr 1: 167.14 – 167.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the TMCO1 gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143183 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052428 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  6. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  7. ^ "Entrez Gene: TMCO1 transmembrane and coiled-coil domains 1".

Further reading

  • Iwamuro S, Saeki M, Kato S (1999). "Multi-ubiquitination of a nascent membrane protein produced in a rabbit reticulocyte lysate". J. Biochem. 126 (1): 48–53. doi:10.1093/oxfordjournals.jbchem.a022435. PMID 10393320.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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