TFB2M

Protein-coding gene in the species Homo sapiens
TFB2M
Identifiers
AliasesTFB2M, Hkp1, mtTFB2, transcription factor B2, mitochondrial
External IDsOMIM: 607055; MGI: 107937; HomoloGene: 7362; GeneCards: TFB2M; OMA:TFB2M - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TFB2M
Genomic location for TFB2M
Band1q44Start246,540,561 bp[1]
End246,566,261 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for TFB2M
Genomic location for TFB2M
Band1 H4|1 83.56 cMStart179,355,620 bp[2]
End179,373,832 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • palpebral conjunctiva

  • right adrenal gland

  • right adrenal cortex

  • biceps brachii

  • tibia

  • left adrenal gland

  • right lobe of liver

  • parietal pleura

  • Skeletal muscle tissue of biceps brachii
Top expressed in
  • muscle of thigh

  • quadriceps femoris muscle

  • muscle tissue

  • skeletal muscle tissue

  • tail of embryo

  • zygote

  • renal cortex

  • proximal tubule

  • heart

  • epiblast
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • methyltransferase activity
  • transferase activity
  • transcription coregulator activity
  • rRNA methyltransferase activity
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
  • RNA binding
Cellular component
  • cell junction
  • mitochondrial nucleoid
  • mitochondrial matrix
  • mitochondrion
Biological process
  • positive regulation of transcription, DNA-templated
  • rRNA processing
  • methylation
  • mitochondrion organization
  • regulation of transcription, DNA-templated
  • rRNA methylation
  • transcription, DNA-templated
  • mitochondrial transcription
  • transcription initiation from mitochondrial promoter
  • rRNA modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64216

15278

Ensembl

ENSG00000162851

ENSMUSG00000026492

UniProt

Q9H5Q4

Q3TL26

RefSeq (mRNA)

NM_022366

NM_008249
NM_001331054
NM_001331055

RefSeq (protein)

NP_071761

NP_001317983
NP_001317984
NP_032275

Location (UCSC)Chr 1: 246.54 – 246.57 MbChr 1: 179.36 – 179.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dimethyladenosine transferase 2; transcription factor B2, mitochondrial is an enzyme that in humans is encoded by the TFB2M gene.[5]

This protein is a transcription initiation factor for the mitochondrial RNA polymerase, POLRMT. Its paralog TFB1M can perform a similar function, but only in vitro.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162851 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026492 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TFB2M transcription factor B2, mitochondrial".
  6. ^ Hillen, HS; Morozov, YI; Sarfallah, A; Temiakov, D; Cramer, P (16 November 2017). "Structural Basis of Mitochondrial Transcription Initiation". Cell. 171 (5): 1072–1081.e10. doi:10.1016/j.cell.2017.10.036. PMC 6590061. PMID 29149603.

Further reading

  • Falkenberg M, Gaspari M, Rantanen A, et al. (2002). "Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA". Nat. Genet. 31 (3): 289–94. doi:10.1038/ng909. PMID 12068295. S2CID 11164308.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Rantanen A, Gaspari M, Falkenberg M, et al. (2003). "Characterization of the mouse genes for mitochondrial transcription factors B1 and B2". Mamm. Genome. 14 (1): 1–6. doi:10.1007/s00335-002-2218-z. PMID 12532263. S2CID 25379746.
  • McCulloch V, Shadel GS (2003). "Human mitochondrial transcription factor B1 interacts with the C-terminal activation region of h-mtTFA and stimulates transcription independently of its RNA methyltransferase activity". Mol. Cell. Biol. 23 (16): 5816–24. doi:10.1128/MCB.23.16.5816-5824.2003. PMC 166325. PMID 12897151.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gaspari M, Falkenberg M, Larsson NG, Gustafsson CM (2005). "The mitochondrial RNA polymerase contributes critically to promoter specificity in mammalian cells". EMBO J. 23 (23): 4606–14. doi:10.1038/sj.emboj.7600465. PMC 533051. PMID 15526033.
  • Gleyzer N, Vercauteren K, Scarpulla RC (2005). "Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators". Mol. Cell. Biol. 25 (4): 1354–66. doi:10.1128/MCB.25.4.1354-1366.2005. PMC 548005. PMID 15684387.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Cotney J, Shadel GS (2007). "Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2". J. Mol. Evol. 63 (5): 707–17. doi:10.1007/s00239-006-0075-1. PMID 17031457. S2CID 7673903.
  • Cotney J, Wang Z, Shadel GS (2007). "Relative abundance of the human mitochondrial transcription system and distinct roles for h-mtTFB1 and h-mtTFB2 in mitochondrial biogenesis and gene expression". Nucleic Acids Res. 35 (12): 4042–54. doi:10.1093/nar/gkm424. PMC 1919481. PMID 17557812.


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