SYPL1

Protein-coding gene in the species Homo sapiens
SYPL1
Identifiers
AliasesSYPL1, H-SP1, SYPL, synaptophysin like 1
External IDsOMIM: 616665; MGI: 108081; HomoloGene: 4915; GeneCards: SYPL1; OMA:SYPL1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for SYPL1
Genomic location for SYPL1
Band7q22.3Start106,090,503 bp[1]
End106,112,576 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for SYPL1
Genomic location for SYPL1
Band12 A3|12 13.87 cMStart33,003,890 bp[2]
End33,029,859 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • epithelium of nasopharynx

  • C1 segment

  • germinal epithelium

  • mucosa of paranasal sinus

  • olfactory zone of nasal mucosa

  • parotid gland

  • gingival epithelium

  • minor salivary glands

  • mucosa of pharynx

  • oral cavity
Top expressed in
  • spermatid

  • conjunctival fornix

  • corneal stroma

  • ascending aorta

  • parotid gland

  • crypt of lieberkuhn of small intestine

  • aortic valve

  • seminal vesicula

  • transitional epithelium of urinary bladder

  • triceps brachii muscle
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • transporter activity
  • syntaxin-1 binding
Cellular component
  • synaptic vesicle
  • secretory granule
  • cytoplasmic vesicle membrane
  • membrane
  • melanosome
  • cytoplasmic vesicle
  • integral component of synaptic vesicle membrane
  • integral component of membrane
  • integral component of plasma membrane
  • extracellular exosome
  • synaptic vesicle membrane
Biological process
  • chemical synaptic transmission
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6856

19027

Ensembl

ENSG00000008282

ENSMUSG00000020570

UniProt

Q16563

O09117

RefSeq (mRNA)

NM_006754
NM_182715

NM_013635
NM_198710

RefSeq (protein)
NP_006745
NP_874384
NP_001368839
NP_001368840
NP_001368841

NP_001368842
NP_001368844
NP_001368845
NP_001368846
NP_001368847
NP_001368848
NP_001368849
NP_001368850

NP_038663
NP_942003

Location (UCSC)Chr 7: 106.09 – 106.11 MbChr 12: 33 – 33.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptophysin-like protein 1 is a protein that in humans is encoded by the SYPL1 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000008282 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020570 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SYPL1 synaptophysin-like 1".

Further reading

  • Zhong CZ, Hayzer DJ, Runge MS (1992). "Molecular cloning of a cDNA encoding a novel protein related to the neuronal vesicle protein synaptophysin". Biochim. Biophys. Acta. 1129 (2): 235–8. doi:10.1016/0167-4781(92)90495-l. PMID 1730063.
  • Leube RE (1994). "Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human". Differentiation. 56 (3): 163–71. doi:10.1046/j.1432-0436.1994.5630163.x. PMID 8034131.
  • Haass NK, Kartenbeck MA, Leube RE (1996). "Pantophysin is a ubiquitously expressed synaptophysin homologue and defines constitutive transport vesicles". J. Cell Biol. 134 (3): 731–46. doi:10.1083/jcb.134.3.731. PMC 2120938. PMID 8707851.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Windoffer R, Borchert-Stuhlträger M, Haass NK, et al. (1999). "Tissue expression of the vesicle protein pantophysin". Cell Tissue Res. 296 (3): 499–510. doi:10.1007/s004410051310. PMID 10370136. S2CID 6765747.
  • Brooks CC, Scherer PE, Cleveland K, et al. (2000). "Pantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4-containing vesicles". J. Biol. Chem. 275 (3): 2029–36. doi:10.1074/jbc.275.3.2029. PMID 10636906.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.


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