SYNPR

Protein-coding gene in the species Homo sapiens
SYNPR
Identifiers
AliasesSYNPR, SPO, synaptoporin
External IDsMGI: 1919253; HomoloGene: 11407; GeneCards: SYNPR; OMA:SYNPR - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SYNPR
Genomic location for SYNPR
Band3p14.2Start63,228,315 bp[1]
End63,616,924 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for SYNPR
Genomic location for SYNPR
Band14|14 A1Start8,853,423 bp[2]
End9,184,983 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • cerebellar vermis

  • nucleus accumbens

  • external globus pallidus

  • Brodmann area 46

  • middle temporal gyrus

  • caudate nucleus

  • cerebellar hemisphere

  • superior frontal gyrus

  • Brodmann area 23
Top expressed in
  • habenula

  • olfactory tubercle

  • dorsomedial hypothalamic nucleus

  • dentate gyrus

  • nucleus accumbens

  • globus pallidus

  • dentate gyrus of hippocampal formation granule cell

  • suprachiasmatic nucleus

  • lobe of cerebellum

  • neural layer of retina
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • syntaxin-1 binding
Cellular component
  • synapse
  • membrane
  • cell junction
  • cytoplasmic vesicle
  • integral component of synaptic vesicle membrane
  • synaptic vesicle membrane
  • neuron projection
  • integral component of membrane
  • synaptic vesicle
Biological process
  • transport
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

132204

72003

Ensembl

ENSG00000163630

ENSMUSG00000056296

UniProt

Q8TBG9

Q8BGN8

RefSeq (mRNA)

NM_001130003
NM_144642

NM_001163032
NM_028052

RefSeq (protein)

NP_001123475
NP_653243

NP_001156504
NP_082328

Location (UCSC)Chr 3: 63.23 – 63.62 MbChr 14: 8.85 – 9.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Synaptoporin is a protein that in humans is encoded by the SYNPR gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163630 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056296 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Leube RE (Aug 1994). "Expression of the synaptophysin gene family is not restricted to neuronal and neuroendocrine differentiation in rat and human". Differentiation. 56 (3): 163–71. doi:10.1046/j.1432-0436.1994.5630163.x. PMID 8034131.
  6. ^ Dai J, Ji C, Gu S, Wu Q, Wang L, Xu J, Zeng L, Ye X, Yin G, Xie Y, Mao Y (Sep 2003). "Cloning and sequence analysis of the human cDNA encoding the synaptoporin (delta), a highly conservative synaptic vesicle protein". Mol Biol Rep. 30 (3): 185–91. doi:10.1023/A:1024907723000. PMID 12974474. S2CID 40874195.
  7. ^ "Entrez Gene: SYNPR synaptoporin".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Singec I, Knoth R, Ditter M, et al. (2002). "Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons". J. Comp. Neurol. 452 (2): 139–53. doi:10.1002/cne.10371. PMID 12271488. S2CID 30492933.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Tran MH, Yamada K, Nakajima A, et al. (2004). "Tyrosine nitration of a synaptic protein synaptophysin contributes to amyloid beta-peptide-induced cholinergic dysfunction". Mol. Psychiatry. 8 (4): 407–12. doi:10.1038/sj.mp.4001240. PMID 12740598. S2CID 23487661.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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