STAMBPL1

Protein-coding gene in the species Homo sapiens
STAMBPL1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2ZNR, 2ZNV

Identifiers
AliasesSTAMBPL1, ALMalpha, AMSH-FP, AMSH-LP, bA399O19.2, STAM binding protein like 1
External IDsOMIM: 612352; MGI: 1923880; HomoloGene: 23253; GeneCards: STAMBPL1; OMA:STAMBPL1 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for STAMBPL1
Genomic location for STAMBPL1
Band10q23.31Start88,879,734 bp[1]
End88,975,153 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for STAMBPL1
Genomic location for STAMBPL1
Band19|19 C1Start34,169,629 bp[2]
End34,217,733 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of ileum

  • endothelial cell

  • Brodmann area 23

  • mucosa of sigmoid colon

  • middle temporal gyrus

  • primary visual cortex

  • pancreatic epithelial cell

  • cardiac muscle tissue of right atrium

  • stromal cell of endometrium

  • epithelium of nasopharynx
Top expressed in
  • spermatid

  • seminiferous tubule

  • thymus

  • granulocyte

  • epithelium of small intestine

  • spermatocyte

  • stria vascularis

  • gastrula

  • tibiofemoral joint

  • visual cortex
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • peptidase activity
  • protein binding
  • hydrolase activity
  • metallopeptidase activity
  • metal ion binding
  • Lys63-specific deubiquitinase activity
  • thiol-dependent deubiquitinase
Cellular component
  • membrane
  • cytosol
  • endosome
Biological process
  • proteolysis
  • protein deubiquitination
  • protein K63-linked deubiquitination
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

57559

76630

Ensembl

ENSG00000138134

ENSMUSG00000024776

UniProt

Q96FJ0

Q76N33

RefSeq (mRNA)

NM_020799

NM_029682
NM_001360716
NM_001360717
NM_001360718
NM_001360719

NM_001360720

RefSeq (protein)

NP_065850

NP_083958
NP_001347645
NP_001347646
NP_001347647
NP_001347648

NP_001347649

Location (UCSC)Chr 10: 88.88 – 88.98 MbChr 19: 34.17 – 34.22 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AMSH-like protease is an enzyme that in humans is encoded by the STAMBPL1 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138134 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024776 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kikuchi K, Ishii N, Asao H, Sugamura K (Jun 2003). "Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif". Biochem Biophys Res Commun. 306 (3): 637–43. doi:10.1016/S0006-291X(03)01009-X. PMID 12810066.
  6. ^ Kitajima K, Matsumoto K, Tahara M, Takahashi H, Nakamura T, Nakamura T (Aug 2003). "A newly identified AMSH-family protein is specifically expressed in haploid stages of testicular germ cells". Biochem Biophys Res Commun. 309 (1): 135–42. doi:10.1016/S0006-291X(03)01550-X. PMID 12943674.
  7. ^ "Entrez Gene: STAMBPL1 STAM binding protein-like 1".

Further reading

  • Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ibarrola N, Kratchmarova I, Nakajima D, et al. (2004). "Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling". BMC Cell Biol. 5: 2. doi:10.1186/1471-2121-5-2. PMC 385422. PMID 14728725.
  • Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.
  • Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Nakamura M, Tanaka N, Kitamura N, Komada M (2006). "Clathrin anchors deubiquitinating enzymes, AMSH and AMSH-like protein, on early endosomes". Genes Cells. 11 (6): 593–606. doi:10.1111/j.1365-2443.2006.00963.x. PMID 16716190. S2CID 30077507.
  • Reyes-Ibarra AP, García-Regalado A, Ramírez-Rangel I, et al. (2007). "Calcium-sensing receptor endocytosis links extracellular calcium signaling to parathyroid hormone-related peptide secretion via a Rab11a-dependent and AMSH-sensitive mechanism". Mol. Endocrinol. 21 (6): 1394–407. doi:10.1210/me.2006-0523. PMID 17426287.


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