SRCAP

Protein-coding gene in the species Homo sapiens
SRCAP
Identifiers
AliasesSRCAP, DOMO1, EAF1, FLHS, SWR1, Snf2-related CREBBP activator protein, Snf2 related CREBBP activator protein, DEHMBA
External IDsOMIM: 611421; MGI: 2444036; HomoloGene: 38213; GeneCards: SRCAP; OMA:SRCAP - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for SRCAP
Genomic location for SRCAP
Band16p11.2Start30,698,209 bp[1]
End30,741,409 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SRCAP
Genomic location for SRCAP
Band7|7 F3Start127,111,155 bp[2]
End127,160,391 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • stromal cell of endometrium

  • granulocyte

  • epithelium of colon

  • appendix

  • body of uterus

  • gastric mucosa

  • apex of heart

  • gastrocnemius muscle

  • muscle of thigh
Top expressed in
  • genital tubercle

  • tail of embryo

  • neural layer of retina

  • zygote

  • Rostral migratory stream

  • dentate gyrus of hippocampal formation granule cell

  • lip

  • ventricular zone

  • primary visual cortex

  • muscle of thigh
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • transcription coactivator activity
  • nucleotide binding
  • protein binding
  • ATP binding
  • hydrolase activity
  • helicase activity
  • histone acetyltransferase activity
  • ATPase activity
  • histone binding
Cellular component
  • perinuclear region of cytoplasm
  • Golgi apparatus
  • nucleus
  • nucleoplasm
  • nuclear body
  • protein-containing complex
  • Swr1 complex
Biological process
  • regulation of transcription by RNA polymerase II
  • viral process
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • histone acetylation
  • chromatin organization
  • positive regulation of nucleic acid-templated transcription
  • chromatin remodeling
  • histone exchange
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10847

100043597

Ensembl

ENSG00000080603

ENSMUSG00000053877

UniProt

Q6ZRS2

n/a

RefSeq (mRNA)

NM_006662

NM_001033881
NM_001304266
NM_175144
NM_178800

RefSeq (protein)

NP_006653

n/a

Location (UCSC)Chr 16: 30.7 – 30.74 MbChr 7: 127.11 – 127.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Helicase SRCAP is an enzyme that in humans is encoded by the SRCAP gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000080603 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053877 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J (Jul 1999). "Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein". J Biol Chem. 274 (23): 16370–6. doi:10.1074/jbc.274.23.16370. PMID 10347196.
  6. ^ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Sep 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  7. ^ "Entrez Gene: SRCAP Snf2-related CBP activator protein".

Further reading

  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Ghosh AK, Majumder M, Steele R, et al. (2000). "Hepatitis C virus NS5A protein modulates transcription through a novel cellular transcription factor SRCAP". J. Biol. Chem. 275 (10): 7184–8. doi:10.1074/jbc.275.10.7184. PMID 10702287.
  • Xu X, Chackalaparampil I, Monroy MA, et al. (2001). "Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription". J. Virol. 75 (21): 10033–40. doi:10.1128/JVI.75.21.10033-10040.2001. PMC 114578. PMID 11581372.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Monroy MA, Schott NM, Cox L, et al. (2004). "SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1". Mol. Endocrinol. 17 (12): 2519–28. doi:10.1210/me.2003-0208. PMID 14500758.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
  • Eissenberg JC, Wong M, Chrivia JC (2005). "Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway". Mol. Cell. Biol. 25 (15): 6559–69. doi:10.1128/MCB.25.15.6559-6569.2005. PMC 1190335. PMID 16024792.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ruhl DD, Jin J, Cai Y, et al. (2006). "Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes". Biochemistry. 45 (17): 5671–7. doi:10.1021/bi060043d. PMID 16634648.
  • Cai Y, Jin J, Gottschalk AJ, et al. (2007). "Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes". Methods. 40 (4): 312–7. doi:10.1016/j.ymeth.2006.06.023. PMC 3092633. PMID 17101442.
  • Wong MM, Cox LK, Chrivia JC (2007). "The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters". J. Biol. Chem. 282 (36): 26132–9. doi:10.1074/jbc.M703418200. PMID 17617668.

External links

  • OMIM entry on Floating-Harbor syndrome and SRCAP


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