SNX27

Protein-coding gene in the species Homo sapiens

SNX27

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
4HAS

Identifiers

Aliases

SNX27, MRT1, MY014, sorting nexin family member 27, sorting nexin 27

External IDs

OMIM: 611541; MGI: 1923992; HomoloGene: 12797; GeneCards: SNX27; OMA:SNX27 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q21.3	Start	151,612,006 bp^[1]
Band	1q21.3	End	151,699,091 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 F2.1	Start	94,404,851 bp^[2]
Band	3\|3 F2.1	End	94,490,023 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

internal globus pallidus

optic nerve

external globus pallidus

superior vestibular nucleus

inferior ganglion of vagus nerve

lateral nuclear group of thalamus

ventral tegmental area

subthalamic nucleus

monocyte

Pars compacta

Top expressed in

otic vesicle

tail of embryo

otolith organ

utricle

Rostral migratory stream

ventromedial nucleus

lateral septal nucleus

dentate gyrus of hippocampal formation granule cell

hand

spermatocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	phosphatidylinositol-3-phosphate binding protein binding phosphatidylinositol binding lipid binding
Cellular component	early endosome membrane membrane nucleoplasm retromer complex early endosome immunological synapse WASH complex cytoplasm endosome cytosol
Biological process	establishment of natural killer cell polarity endosome to lysosome transport endosomal transport protein transport intracellular protein transport signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


81609


76742

Ensembl


ENSG00000143376


ENSMUSG00000028136

UniProt


Q96L92


Q3UHD6

RefSeq (mRNA)


NM_030918 NM_001330723


NM_001082484 NM_029721

RefSeq (protein)


NP_001317652 NP_112180


NP_001075953 NP_083997

Location (UCSC)

Chr 1: 151.61 – 151.7 Mb

Chr 3: 94.4 – 94.49 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Sorting nexin family member 27, also known as SNX27, is a human gene.^[5]

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143376 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028136 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: SNX27 sorting nexin family member 27".

Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins". Nature Reviews. Molecular Cell Biology. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF (July 2004). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Molecular Biology of the Cell. 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMC 452567. PMID 15121882.
Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J (October 2004). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". Journal of Cell Science. 117 (Pt 22): 5367–79. doi:10.1242/jcs.01379. PMID 15466885.
Rincón E, Santos T, Avila-Flores A, Albar JP, Lalioti V, Lei C, Hong W, Mérida I (June 2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling". Molecular & Cellular Proteomics. 6 (6): 1073–87. doi:10.1074/mcp.M700047-MCP200. PMID 17351151.
MacNeil AJ, Mansour M, Pohajdak B (August 2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochemical and Biophysical Research Communications. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.