Protein-coding gene in the species Homo sapiens
| SELENOT |
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| Identifiers |
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| Aliases | SELENOT, SELT, selenoprotein T |
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| External IDs | OMIM: 607912; MGI: 1916477; HomoloGene: 32304; GeneCards: SELENOT; OMA:SELENOT - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 3 (human)[1] |
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| | Band | 3q25.1 | Start | 150,602,875 bp[1] |
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| End | 150,630,436 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 3 (mouse)[2] |
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| | Band | 3|3 D | Start | 58,484,057 bp[2] |
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| End | 58,500,554 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - islet of Langerhans
- right adrenal gland
- right adrenal cortex
- internal globus pallidus
- left adrenal gland
- monocyte
- beta cell
- stromal cell of endometrium
- left adrenal cortex
- prefrontal cortex
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| | Top expressed in | - olfactory epithelium
- iris
- median eminence
- sciatic nerve
- primitive streak
- Epithelium of choroid plexus
- barrel cortex
- Region I of hippocampus proper
- vestibular membrane of cochlear duct
- endothelial cell of lymphatic vessel
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function | - selenium binding
- thioredoxin-disulfide reductase activity
- oxidoreductase activity
| | Cellular component | - endoplasmic reticulum
- endoplasmic reticulum membrane
- membrane
- integral component of membrane
| | Biological process | - selenocysteine incorporation
- positive regulation of cytosolic calcium ion concentration
- positive regulation of growth hormone secretion
- cellular oxidant detoxification
- response to glucose
- pancreas development
- insulin secretion involved in cellular response to glucose stimulus
- glucose homeostasis
- cell redox homeostasis
| | Sources:Amigo / QuickGO |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Selenoprotein T, also known as SELT, is a protein that in humans is encoded by the SELT gene.[5][6][7]
Gene
The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.[7]
Protein structure
Selenoprotein T contains a selenocysteine (Sec) residue at its active site.
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198843 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075700 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kryukov GV, Kryukov VM, Gladyshev VN (November 1999). "New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements". J. Biol. Chem. 274 (48): 33888–97. doi:10.1074/jbc.274.48.33888. PMID 10567350.
- ^ Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN (May 2003). "Characterization of mammalian selenoproteomes". Science. 300 (5624): 1439–43. Bibcode:2003Sci...300.1439K. doi:10.1126/science.1083516. PMID 12775843. S2CID 10363908.
- ^ a b "Entrez Gene: SELT selenoprotein T".
Further reading
- Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
