SCRN1

Protein-coding gene in the species Homo sapiens
SCRN1
Identifiers
AliasesSCRN1, SES1, secernin 1
External IDsOMIM: 614965; MGI: 1917188; HomoloGene: 8853; GeneCards: SCRN1; OMA:SCRN1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for SCRN1
Genomic location for SCRN1
Band7p14.3Start29,920,104 bp[1]
End29,990,289 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for SCRN1
Genomic location for SCRN1
Band6|6 B3Start54,478,158 bp[2]
End54,543,474 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • trigeminal ganglion

  • cerebellar vermis

  • ventricular zone

  • pons

  • pars reticulata

  • superior vestibular nucleus

  • olfactory bulb

  • Pars compacta

  • paraflocculus of cerebellum

  • spinal ganglia
Top expressed in
  • otolith organ

  • utricle

  • habenula

  • superior cervical ganglion

  • paraventricular nucleus of hypothalamus

  • dorsal striatum

  • arcuate nucleus

  • median eminence

  • dorsomedial hypothalamic nucleus

  • ventral tegmental area
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • dipeptidase activity
  • molecular function
Cellular component
  • cytoplasm
  • nuclear membrane
  • nucleus
Biological process
  • proteolysis
  • exocytosis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9805

69938

Ensembl

ENSG00000136193

ENSMUSG00000019124

UniProt

Q12765

Q9CZC8

RefSeq (mRNA)

NM_001145513
NM_001145514
NM_001145515
NM_014766

NM_027268

RefSeq (protein)

NP_001138985
NP_001138986
NP_001138987
NP_055581

NP_081544

Location (UCSC)Chr 7: 29.92 – 29.99 MbChr 6: 54.48 – 54.54 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Secernin-1 is a protein that in humans is encoded by the SCRN1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136193 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019124 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Way G, Morrice N, Smythe C, O'Sullivan AJ (Sep 2002). "Purification and identification of secernin, a novel cytosolic protein that regulates exocytosis in mast cells" (PDF). Mol Biol Cell. 13 (9): 3344–54. doi:10.1091/mbc.E01-10-0094. PMC 124164. PMID 12221138.
  6. ^ "Entrez Gene: SCRN1 secernin 1".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Nagase T, Seki N, Ishikawa K, et al. (1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  • Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
  • Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
  • O'Neill EE, Brock CJ, von Kriegsheim AF, et al. (2002). "Towards complete analysis of the platelet proteome". Proteomics. 2 (3): 288–305. doi:10.1002/1615-9861(200203)2:3<288::AID-PROT288>3.0.CO;2-0. PMID 11921445. S2CID 20643741.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suda T, Tsunoda T, Uchida N, et al. (2006). "Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray". Cancer Sci. 97 (5): 411–9. doi:10.1111/j.1349-7006.2006.00194.x. PMC 11159625. PMID 16630140. S2CID 25739515.


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