RTFDC1

Protein-coding gene in the species Homo sapiens
RTF1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2BZE, 2DB9, 3U1U, 4L1P, 4L1U

Identifiers
Aliases15890 RTF1, RTF2, GTL7, KIAA0252, RTF1 homolog, Paf1/RNA polymerase II complex component, RTF2, C20orf43, CDAO5, HSPC164, SHUJUN-3, replication termination factor 2 domain containing 1, replication termination factor 2, RTFDC1
External IDsOMIM: 611633; MGI: 1309480; HomoloGene: 133868 9501; GeneCards: RTF2 RTF1, RTF2; OMA:RTF1, RTF2 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for RTF1
Genomic location for RTF1
Band15q15.1, 20q13.31Start41,408,408 bp[1]
End41,483,563 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for RTF1
Genomic location for RTF1
Band2|2 E5Start119,675,068 bp[2]
End119,735,407 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • Skeletal muscle tissue of rectus abdominis

  • palpebral conjunctiva

  • epithelium of colon

  • ventricular zone

  • bone marrow cells

  • cerebellar hemisphere

  • Skeletal muscle tissue of biceps brachii

  • body of tongue

  • monocyte
Top expressed in
  • tail of embryo

  • zygote

  • genital tubercle

  • hand

  • yolk sac

  • superior cervical ganglion

  • foot

  • interventricular septum

  • primitive streak

  • fossa
More reference expression data
BioGPS
51507/ More reference expression data
Gene ontology
Molecular function
  • protein binding
  • single-stranded DNA binding
  • DNA binding
  • RNA polymerase II C-terminal domain phosphoserine binding
  • RNA binding
  • molecular function
Cellular component
  • nucleolus
  • nucleus
  • Cdc73/Paf1 complex
  • nucleoplasm
  • cellular component
  • replication fork
  • chromosome
Biological process
  • blastocyst growth
  • histone modification
  • regulation of transcription, DNA-templated
  • positive regulation of transcription elongation from RNA polymerase II promoter
  • histone H3-K4 trimethylation
  • positive regulation of histone H3-K4 methylation
  • transcription, DNA-templated
  • Wnt signaling pathway
  • positive regulation of transcription by RNA polymerase II
  • negative regulation of transcription by RNA polymerase II
  • stem cell population maintenance
  • endodermal cell fate commitment
  • transcription by RNA polymerase II
  • transcription elongation from RNA polymerase II promoter
  • protein ubiquitination
  • mitotic DNA replication termination
  • site-specific DNA replication termination at RTS1 barrier
  • biological process
  • cellular response to hydroxyurea
  • regulation of DNA stability
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23168,51507
23168,51507

76246

Ensembl

ENSG00000137815
ENSG00000022277

ENSMUSG00000027304

UniProt

Q92541
Q9BY42

A2AQ19

RefSeq (mRNA)

NM_015138
NM_001283035
NM_001283036
NM_001283037
NM_016407

NM_030112

RefSeq (protein)

NP_055953
NP_001269964
NP_001269965
NP_001269966
NP_057491

NP_084388

Location (UCSC)Chr 15: 41.41 – 41.48 MbChr 2: 119.68 – 119.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Replication termination factor 2 is a protein that in humans is encoded by the RTF2 gene.[5]

References

  1. ^ a b c ENSG00000022277 GRCh38: Ensembl release 89: ENSG00000137815, ENSG00000022277 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027304 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "RTF2 replication termination factor 2 [ Homo sapiens (human) ]".

External links

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  • Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.


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