RTF1

Protein

RTF1

Identifiers

Aliases

External IDs

GeneCards: [1]; OMA:- orthologs

Orthologs

Species

Human

Mouse

Entrez


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Ensembl


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UniProt


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RefSeq (mRNA)


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RefSeq (protein)


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Location (UCSC)

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PubMed search

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Wikidata

View/Edit Human

Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) is a protein that in humans is encoded by the RTF1 gene.^[1]

This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA.^[1]

References

^ ^a ^b "Entrez Gene: Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)". Retrieved 2011-09-20.

Rozenblatt-Rosen O, Hughes CM, Nannepaga SJ, Shanmugam KS, Copeland TD, Guszczynski T, et al. (January 2005). "The parafibromin tumor suppressor protein is part of a human Paf1 complex". Molecular and Cellular Biology. 25 (2): 612–620. doi:10.1128/MCB.25.2.612-620.2005. PMC 543415. PMID 15632063.
Warner MH, Roinick KL, Arndt KM (September 2007). "Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification". Molecular and Cellular Biology. 27 (17): 6103–6115. doi:10.1128/MCB.00772-07. PMC 1952162. PMID 17576814.
de Jong RN, Truffault V, Diercks T, Ab E, Daniels MA, Kaptein R, et al. (January 2008). "Structure and DNA binding of the human Rtf1 Plus3 domain". Structure. 16 (1): 149–159. doi:10.1016/j.str.2007.10.018. hdl:1874/33204. PMID 18184592. S2CID 38494347.
Nordick K, Hoffman MG, Betz JL, Jaehning JA (July 2008). "Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II". Eukaryotic Cell. 7 (7): 1158–1167. doi:10.1128/EC.00434-07. PMC 2446681. PMID 18469135.
Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, et al. (October 2010). "Hundreds of variants clustered in genomic loci and biological pathways affect human height". Nature. 467 (7317): 832–838. Bibcode:2010Natur.467..832L. doi:10.1038/nature09410. PMC 2955183. PMID 20881960.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, et al. (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–329, 341–329. doi:10.1093/dnares/3.5.321. PMID 9039502.