RRP12

Protein-coding gene in the species Homo sapiens


RRP12
Identifiers
AliasesRRP12, KIAA0690, ribosomal RNA processing 12 homolog
External IDsOMIM: 617723; MGI: 2147437; HomoloGene: 22370; GeneCards: RRP12; OMA:RRP12 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for RRP12
Genomic location for RRP12
Band10q24.1Start97,356,358 bp[1]
End97,426,076 bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for RRP12
Genomic location for RRP12
Band19|19 C3Start41,851,290 bp[2]
End41,884,612 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gastrocnemius muscle

  • monocyte

  • bone marrow cells

  • muscle of thigh

  • anterior pituitary

  • granulocyte

  • testicle

  • blood

  • body of pancreas

  • apex of heart
Top expressed in
  • otic placode

  • otic vesicle

  • saccule

  • muscle of thigh

  • epiblast

  • spermatid

  • primitive streak

  • seminiferous tubule

  • spermatocyte

  • yolk sac
More reference expression data
BioGPS


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23223

107094

Ensembl

ENSG00000052749

ENSMUSG00000035049

UniProt

Q5JTH9

Q6P5B0

RefSeq (mRNA)

NM_001145114
NM_001284337
NM_015179

NM_199447

RefSeq (protein)

NP_001138586
NP_001271266
NP_055994

NP_955518

Location (UCSC)Chr 10: 97.36 – 97.43 MbChr 19: 41.85 – 41.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RRP12-like protein is a protein that in humans is encoded by the RRP12 gene.[5][6] It is currently thought to be involved in ribosome assembly of the precursor particles of both subunits in eukaryotes and was identified as a RNA binding protein.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000052749 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035049 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ "Entrez Gene: RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)".
  7. ^ Oeffinger M, Dlakic M, Tollervey D (January 2004). "A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits". Genes & Development. 18 (2): 196–209. doi:10.1101/gad.285604. PMC 324425. PMID 14729571.
  8. ^ Moriggi G, Nieto B, Dosil M (December 2014). "Rrp12 and the Exportin Crm1 participate in late assembly events in the nucleolus during 40S ribosomal subunit biogenesis". PLOS Genetics. 10 (12): e1004836. doi:10.1371/journal.pgen.1004836. PMC 4256259. PMID 25474739.

Further reading

  • Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002). "Directed proteomic analysis of the human nucleolus". Current Biology. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
  • Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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