RPAIN

Protein-coding gene in the species Homo sapiens
RPAIN
Identifiers
AliasesRPAIN, HRIP, RIP, RPA interacting protein
External IDsOMIM: 617299; MGI: 1916973; HomoloGene: 13006; GeneCards: RPAIN; OMA:RPAIN - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for RPAIN
Genomic location for RPAIN
Band17p13.2Start5,419,641 bp[1]
End5,432,877 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for RPAIN
Genomic location for RPAIN
Band11|11 B4Start70,861,039 bp[2]
End70,868,659 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • middle temporal gyrus

  • anterior pituitary

  • ventricular zone

  • sperm

  • left ovary

  • Brodmann area 23

  • right ovary

  • muscle of thigh

  • gastrocnemius muscle
Top expressed in
  • spermatid

  • spermatocyte

  • right kidney

  • yolk sac

  • lens

  • neural layer of retina

  • parotid gland

  • ascending aorta

  • neural tube

  • aortic valve
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • metal ion binding
  • protein-containing complex binding
Cellular component
  • cytoplasm
  • PML body
  • nucleus
  • fibrillar center
Biological process
  • DNA-dependent DNA replication
  • DNA recombination
  • response to UV
  • DNA repair
  • protein import into nucleus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84268

69723

Ensembl

ENSG00000129197

ENSMUSG00000018449

UniProt

Q86UA6

Q9CWY9

RefSeq (mRNA)
NM_001033002
NM_001160243
NM_001160244
NM_001160246
NM_001160266

NM_001160267
NM_032308

NM_001252413
NM_001252414
NM_001252415
NM_027186

RefSeq (protein)

NP_001028174
NP_001153715
NP_001153716
NP_001153718
NP_001153738

NP_001239342
NP_001239343
NP_001239344
NP_081462

Location (UCSC)Chr 17: 5.42 – 5.43 MbChr 11: 70.86 – 70.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RPA-interacting protein is a protein that in humans is encoded by the RPAIN gene.[5][6][7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129197 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018449 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Park J, Seo T, Kim H, Choe J (Sep 2005). "Sumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodies". Mol Cell Biol. 25 (18): 8202–14. doi:10.1128/MCB.25.18.8202-8214.2005. PMC 1234305. PMID 16135809.
  6. ^ Chen JZ, Huang SD, Ji CN, Pang RY, Xie Y, Xue JL (Jul 2005). "Identification, expression pattern, and subcellular location of human RIP isoforms". DNA Cell Biol. 24 (7): 464–9. doi:10.1089/dna.2005.24.464. PMID 16008515.
  7. ^ "Entrez Gene: RPAIN RPA interacting protein".

Further reading

  • Blonska M, You Y, Geleziunas R, Lin X (2004). "Restoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells". Mol. Cell. Biol. 24 (24): 10757–65. doi:10.1128/MCB.24.24.10757-10765.2004. PMC 533972. PMID 15572679.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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