RBM6

Protein-coding gene in the species Homo sapiens

RBM6

Identifiers

Aliases

RBM6, 3G2, DEF-3, DEF3, HLC-11, NY-LU-12, g16, RNA binding motif protein 6

External IDs

OMIM: 606886; MGI: 1338037; HomoloGene: 31336; GeneCards: RBM6; OMA:RBM6 - orthologs

Gene location (Human)

Chr.	Chromosome 3 (human)^[1]

Band	3p21.31	Start	49,940,007 bp^[1]
Band	3p21.31	End	50,100,045 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)^[2]

Band	9\|9 F1	Start	107,650,758 bp^[2]
Band	9\|9 F1	End	107,750,436 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

canal of the cervix

gastric mucosa

right uterine tube

right ovary

granulocyte

cerebellar hemisphere

body of uterus

right hemisphere of cerebellum

left ovary

anterior pituitary

Top expressed in

genital tubercle

tail of embryo

neural layer of retina

ventricular zone

spermatocyte

zygote

ganglionic eminence

morula

secondary oocyte

superior frontal gyrus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	DNA binding protein binding nucleic acid binding RNA binding
Cellular component	nucleus
Biological process	RNA processing
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


10180


19654

Ensembl


ENSG00000004534


ENSMUSG00000032582

UniProt


P78332


n/a

RefSeq (mRNA)

NM_001167582 NM_005777 NM_001349190 NM_001349191 NM_001349192
NM_001349193 NM_001349194


NM_011251 NM_029169

RefSeq (protein)

NP_001161054 NP_005768 NP_001336119 NP_001336120 NP_001336121
NP_001336122 NP_001336123


n/a

Location (UCSC)

Chr 3: 49.94 – 50.1 Mb

Chr 9: 107.65 – 107.75 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

RNA-binding protein 6 is a protein that in humans is encoded by the RBM6 gene.^[5]^[6] RBM6 orthologs^[7] have been identified in all mammals for which complete genome data are available.

RBM6 splicing factor interacts with the DNA repair protein RAD51, and is also recruited to DNA double-strand breaks where it promotes homologous recombinational repair.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000004534 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032582 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Voutsinas G, Hulsbeek MM, Draaijers TG, Looman MW, Kok K, Naylor SL, Buys CH (Aug 1999). "A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3". Eur J Hum Genet. 7 (4): 478–86. doi:10.1038/sj.ejhg.5200334. PMID 10352938.
^ "Entrez Gene: RBM6 RNA binding motif protein 6".
^ "OrthoMaM phylogenetic marker: RBM6 coding sequence". Archived from the original on 2016-03-03. Retrieved 2009-12-09.
^ Awwad SW, Darawshe MM, Machour FE, Arman I, Ayoub N. Recruitment of RBM6 to DNA Double-Strand Breaks Fosters Homologous Recombination Repair. Mol Cell Biol. 2023;43(3):130-142. doi: 10.1080/10985549.2023.2187105. PMID: 36941773; PMCID: PMC10038030

Güre AO, Altorki NK, Stockert E, Scanlan MJ, Old LJ, Chen YT (1998). "Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3". Cancer Res. 58 (5): 1034–41. PMID 9500467.
Drabkin HA, West JD, Hotfilder M, Heng YM, Erickson P, Calvo R, Dalmau J, Gemmill RM, Sablitzky F (1999). "DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC". Oncogene. 18 (16): 2589–97. doi:10.1038/sj.onc.1202601. PMID 10353602. S2CID 24925641.
Timmer T, Terpstra P, van den Berg A, Veldhuis PM, Ter Elst A, Van Der Veen AY, Kok K, Naylor SL, Buys CH (1999). "An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers". Genomics. 60 (2): 238–40. doi:10.1006/geno.1999.5878. PMID 10486216.
Lerman MI, Minna JD (2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Res. 60 (21): 6116–33. PMID 11085536.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Gu TL, Mercher T, Tyner JW, Goss VL, Walters DK, Cornejo MG, Reeves C, Popova L, Lee K (2007). "A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia". Blood. 110 (1): 323–33. doi:10.1182/blood-2006-10-052282. PMC 1896120. PMID 17360941.
Wang K, Ubriaco G, Sutherland LC (2007). "RBM6-RBM5 transcription-induced chimeras are differentially expressed in tumours". BMC Genomics. 8: 348. doi:10.1186/1471-2164-8-348. PMC 2174484. PMID 17908320.