RASSF8

Protein-coding gene in the species Homo sapiens
RASSF8
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2CS4

Identifiers
AliasesRASSF8, C12orf2, HOJ1, Ras association domain family member 8
External IDsOMIM: 608231; MGI: 1918573; HomoloGene: 5219; GeneCards: RASSF8; OMA:RASSF8 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for RASSF8
Genomic location for RASSF8
Band12p12.1Start25,959,029 bp[1]
End26,079,892 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for RASSF8
Genomic location for RASSF8
Band6|6 G3Start145,692,474 bp[2]
End145,766,805 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • Achilles tendon

  • stromal cell of endometrium

  • left testis

  • right testis

  • retinal pigment epithelium

  • epithelium of colon

  • sural nerve

  • Skeletal muscle tissue of rectus abdominis

  • secondary oocyte
Top expressed in
  • gastrula

  • ciliary body

  • iris

  • decidua

  • pineal gland

  • vas deferens

  • Epithelium of choroid plexus

  • neural layer of retina

  • stria vascularis

  • efferent ductule
More reference expression data
BioGPS
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11228

71323

Ensembl

ENSG00000123094

ENSMUSG00000030259

UniProt

Q8NHQ8

Q8CJ96

RefSeq (mRNA)

NM_001164746
NM_001164747
NM_001164748
NM_007211

NM_027760

RefSeq (protein)

NP_001158218
NP_001158219
NP_001158220
NP_009142

NP_082036

Location (UCSC)Chr 12: 25.96 – 26.08 MbChr 6: 145.69 – 145.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras association domain-containing protein 8 is a protein that in humans is encoded by the RASSF8 gene.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123094 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030259 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RASSF8 Ras association (RalGDS/AF-6) domain family 8".

Further reading

  • Falvella FS, Spinola M, Manenti G, et al. (2007). "Common polymorphisms in D12S1034 flanking genes RASSF8 and BHLHB3 are not associated with lung adenocarcinoma risk". Lung Cancer. 56 (1): 1–7. doi:10.1016/j.lungcan.2006.11.008. PMID 17194498.
  • Falvella FS, Manenti G, Spinola M, et al. (2006). "Identification of RASSF8 as a candidate lung tumor suppressor gene". Oncogene. 25 (28): 3934–3938. doi:10.1038/sj.onc.1209422. PMID 16462760.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–1450. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Debeer P, Schoenmakers EF, Twal WO, et al. (2002). "The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly". J. Med. Genet. 39 (2): 98–104. doi:10.1136/jmg.39.2.98. PMC 1735038. PMID 11836357.
  • Debeer P, Schoenmakers EF, Thoelen R, et al. (2000). "Physical map of a 1.5 mb region on 12p11.2 harbouring a synpolydactyly associated chromosomal breakpoint". Eur. J. Hum. Genet. 8 (8): 561–570. doi:10.1038/sj.ejhg.5200497. PMID 10951517.
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  • 2cs4: Solution structure of N-terminal domain of chromosome 12 open reading frame 2
    2cs4: Solution structure of N-terminal domain of chromosome 12 open reading frame 2
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