RAB6A

Protein-coding gene in the species Homo sapiens

RAB6A

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1YZQ, 2GIL, 3BBP, 3CWZ, 4DKX

Identifiers

Aliases

RAB6A, RAB6, member RAS oncogene family

External IDs

OMIM: 179513; MGI: 894313; HomoloGene: 55697; GeneCards: RAB6A; OMA:RAB6A - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.4	Start	73,675,638 bp^[1]
Band	11q13.4	End	73,761,137 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 E2	Start	100,256,617 bp^[2]
Band	7\|7 E2	End	100,290,475 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

anterior cingulate cortex

ganglionic eminence

ventricular zone

Brodmann area 10

epithelium of colon

frontal pole

C1 segment

right frontal lobe

stromal cell of endometrium

Top expressed in

primary motor cortex

prefrontal cortex

cingulate gyrus

anterior amygdaloid area

lateral geniculate nucleus

lateral septal nucleus

medial dorsal nucleus

ventral tegmental area

hippocampus proper

dentate gyrus of hippocampal formation granule cell

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding protein domain specific binding GTP binding myosin V binding protein binding GTPase activity
Cellular component	Golgi apparatus membrane endosome to plasma membrane transport vesicle trans-Golgi network extracellular exosome cytoplasmic vesicle trans-Golgi network membrane cytosol endoplasmic reticulum membrane Golgi membrane plasma membrane secretory granule membrane
Biological process	antigen processing and presentation early endosome to Golgi transport peptidyl-cysteine methylation protein localization to Golgi apparatus protein transport minus-end-directed organelle transport along microtubule viral process vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum neutrophil degranulation transport intracellular protein transport intra-Golgi vesicle-mediated transport Rab protein signal transduction retrograde transport, endosome to Golgi
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5870


19346

Ensembl


ENSG00000175582


ENSMUSG00000030704

UniProt


P20340


P35279

RefSeq (mRNA)


NM_198896 NM_001243718 NM_001243719 NM_002869


NM_001163663 NM_024287

RefSeq (protein)


NP_001230647 NP_001230648 NP_002860 NP_942599


NP_001157135 NP_077249

Location (UCSC)

Chr 11: 73.68 – 73.76 Mb

Chr 7: 100.26 – 100.29 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome.^[5] Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.

Interactions

RAB6A has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000175582 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030704 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: RAB6A RAB6A, member RAS oncogene family".
^ ^a ^b Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Curr. Biol. 12 (20): 1792–5. Bibcode:2002CBio...12.1792S. doi:10.1016/s0960-9822(02)01221-6. PMID 12401177.
^ Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nat. Cell Biol. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.
^ Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B (April 2002). "Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport". Traffic. 3 (4): 289–97. doi:10.1034/j.1600-0854.2002.030406.x. PMID 11929610. S2CID 22993226.
^ Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5. Bibcode:1998Sci...279..580E. doi:10.1126/science.279.5350.580. PMID 9438855.
^ Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.

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Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B (1999). "Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome". EMBO J. 18 (7): 1772–82. doi:10.1093/emboj/18.7.1772. PMC 1171263. PMID 10202141.
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Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (2001). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.
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PDB gallery

1yzq: GppNHp-Bound Rab6 GTPase
2fe4: The crystal structure of human neuronal Rab6B in its inactive GDP-bound form
2ffq: The crystal structure of human neuronal Rab6B in its active GTPgS-bound form
2gil: Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8 resolution