RAB38

Protein-coding gene in the species Homo sapiens
RAB38
Identifiers
AliasesRAB38, NY-MEL-1, rrGTPbp, member RAS oncogene family
External IDsOMIM: 606281; MGI: 1919683; HomoloGene: 21353; GeneCards: RAB38; OMA:RAB38 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for RAB38
Genomic location for RAB38
Band11q14.2Start88,113,251 bp[1]
End88,175,443 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for RAB38
Genomic location for RAB38
Band7 D3|7 49.19 cMStart88,079,481 bp[2]
End88,140,780 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gingival epithelium

  • palpebral conjunctiva

  • skin of thigh

  • vulva

  • human penis

  • skin of abdomen

  • hair follicle

  • germinal epithelium

  • oral cavity

  • right adrenal cortex
Top expressed in
  • zygote

  • primary oocyte

  • secondary oocyte

  • molar

  • iris

  • epidermis

  • hair follicle

  • skin of external ear

  • skin of abdomen

  • cornea
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • AP-2 adaptor complex binding
  • nucleotide binding
  • BLOC-2 complex binding
  • GTP binding
  • GTP-dependent protein binding
  • protein binding
  • AP-3 adaptor complex binding
  • AP-1 adaptor complex binding
  • GTPase activity
Cellular component
  • cytoplasm
  • vesicle
  • phagocytic vesicle membrane
  • Golgi apparatus
  • membrane
  • melanosome
  • plasma membrane
  • early endosome
  • phagocytic vesicle
  • endoplasmic reticulum
  • early endosome lumen
  • cytoplasmic vesicle
  • lysosome
  • mitochondrion
  • mitochondria-associated endoplasmic reticulum membrane
  • cytosol
  • melanosome membrane
  • trans-Golgi network
Biological process
  • protein localization to membrane
  • platelet dense granule organization
  • organelle organization
  • phagosome acidification
  • endosome to melanosome transport
  • protein transport
  • melanosome assembly
  • mitochondrion organization
  • vesicle-mediated transport
  • small GTPase mediated signal transduction
  • post-translational protein modification
  • positive regulation of phosphatidylcholine biosynthetic process
  • intracellular protein transport
  • Rab protein signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23682

72433

Ensembl

ENSG00000123892

ENSMUSG00000030559

UniProt

P57729

Q8QZZ8

RefSeq (mRNA)

NM_022337

NM_028238

RefSeq (protein)

NP_071732
NP_071732.1

NP_082514

Location (UCSC)Chr 11: 88.11 – 88.18 MbChr 7: 88.08 – 88.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-38 is a protein that in humans is encoded by the RAB38 gene.[5][6]

In melanocytic cells RAB38 gene expression may be regulated by MITF.[7]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123892 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030559 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jager D, Stockert E, Jager E, Gure AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.
  6. ^ "Entrez Gene: RAB38 RAB38, member RAS oncogene family".
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading

  • Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suzuki T, Miyamura Y, Inagaki K, Tomita Y (2004). "Characterization of the human RAB38 and RAB7 genes: exclusion of new major pathological loci for Japanese OCA". J. Dermatol. Sci. 32 (2): 131–6. doi:10.1016/S0923-1811(03)00071-9. PMID 12850305.
  • Basrur V, Yang F, Kushimoto T, et al. (2003). "Proteomic analysis of early melanosomes: identification of novel melanosomal proteins". J. Proteome Res. 2 (1): 69–79. doi:10.1021/pr025562r. PMID 12643545.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Osanai K, Iguchi M, Takahashi K, et al. (2001). "Expression and Localization of a Novel Rab Small G Protein (Rab38) in the Rat Lung". Am. J. Pathol. 158 (5): 1665–75. doi:10.1016/S0002-9440(10)64122-3. PMC 1891947. PMID 11337364.


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