RAB21

Protein-coding gene in the species Homo sapiens

RAB21

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1YZT, 1YZU, 1Z08, 1Z0I, 2OT3

Identifiers

Aliases

RAB21, member RAS oncogene family

External IDs

OMIM: 612398; MGI: 894308; HomoloGene: 8991; GeneCards: RAB21; OMA:RAB21 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12q21.1	Start	71,754,863 bp^[1]
Band	12q21.1	End	71,800,286 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[2]

Band	10\|10 D2	Start	115,122,989 bp^[2]
Band	10\|10 D2	End	115,151,499 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

Skeletal muscle tissue of rectus abdominis

right ventricle

biceps brachii

gastrocnemius muscle

Skeletal muscle tissue of biceps brachii

Achilles tendon

amniotic fluid

glutes

popliteal artery

tibial arteries

Top expressed in

aortic valve

ascending aorta

supraoptic nucleus

decidua

dorsomedial hypothalamic nucleus

primary oocyte

gastrula

granulocyte

endothelial cell of lymphatic vessel

mammillary body

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	nucleotide binding GDP binding GTP binding protein binding GTPase activity
Cellular component	endosome Golgi apparatus endoplasmic reticulum membrane membrane focal adhesion vesicle membrane Golgi membrane Golgi cisterna membrane trans-Golgi network endoplasmic reticulum neuron projection cytoplasmic side of plasma membrane cytoplasmic side of early endosome membrane cleavage furrow extracellular exosome cytoplasmic vesicle membrane cytoplasmic vesicle axon cytoplasm cytosol early endosome membrane early endosome synapse
Biological process	positive regulation of receptor-mediated endocytosis regulation of axon extension anterograde axonal transport regulation of exocytosis positive regulation of dendrite morphogenesis protein transport positive regulation of early endosome to late endosome transport transport intracellular protein transport Rab protein signal transduction signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


23011


216344

Ensembl


ENSG00000080371


ENSMUSG00000020132

UniProt


Q9UL25


P35282

RefSeq (mRNA)


NM_014999


NM_024454

RefSeq (protein)


NP_055814


NP_077774

Location (UCSC)

Chr 12: 71.75 – 71.8 Mb

Chr 10: 115.12 – 115.15 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-21 is a protein that in humans is encoded by the RAB21 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000080371 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020132 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Opdam FJ, Kamps G, Croes H, van Bokhoven H, Ginsel LA, Fransen JA (Oct 2000). "Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells". Eur J Cell Biol. 79 (5): 308–16. doi:10.1078/S0171-9335(04)70034-5. PMID 10887961.
^ Pereira-Leal JB, Seabra MC (Nov 2001). "Evolution of the Rab family of small GTP-binding proteins". J Mol Biol. 313 (4): 889–901. doi:10.1006/jmbi.2001.5072. PMID 11697911.
^ Pellinen T, Arjonen A, Vuoriluoto K, Kallio K, Fransen JA, Ivaska J (Jun 2006). "Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins". J Cell Biol. 173 (5): 767–80. doi:10.1083/jcb.200509019. PMC 2063892. PMID 16754960.
^ "Entrez Gene: RAB21 RAB21, member RAS oncogene family".

Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
Bao S, Zhu J, Garvey WT (1999). "Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects". Horm. Metab. Res. 30 (11): 656–62. doi:10.1055/s-2007-978953. PMID 9918381. S2CID 23540699.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

PDB gallery

1yzt: GppNHp-Bound Rab21 GTPase at 2.05 A Resolution
1yzu: GppNHp-Bound Rab21 GTPase at 2.50 A Resolution
1z08: GppNHp-Bound Rab21 Q53G mutant GTPase
1z0i: GDP-Bound Rab21 GTPase
2ot3: Crystal structure of rabex-5 VPS9 domain in complex with nucleotide free RAB21