PIF1 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | PIF1, C15orf20, PIF, PIF1 5'-to-3' DNA helicase |
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External IDs | OMIM: 610953; MGI: 2143057; HomoloGene: 99775; GeneCards: PIF1; OMA:PIF1 - orthologs |
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Gene location (Human) |
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![Chromosome 15 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/07/Ideogram_human_chromosome_15.svg/300px-Ideogram_human_chromosome_15.svg.png) | Chr. | Chromosome 15 (human)[1] |
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| Band | 15q22.31 | Start | 64,815,632 bp[1] |
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End | 64,825,668 bp[1] |
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Gene location (Mouse) |
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![Chromosome 9 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/4/41/Ideogram_house_mouse_chromosome_9.svg/260px-Ideogram_house_mouse_chromosome_9.svg.png) | Chr. | Chromosome 9 (mouse)[2] |
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| Band | 9|9 C | Start | 65,587,160 bp[2] |
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End | 65,595,967 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - ventricular zone
- gonad
- ganglionic eminence
- stromal cell of endometrium
- mucosa of transverse colon
- appendix
- granulocyte
- bone marrow cells
- spleen
- lymph node
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| Top expressed in | - otic vesicle
- hand
- Paneth cell
- ventricular zone
- primitive streak
- tail of embryo
- genital tubercle
- endothelial cell of lymphatic vessel
- hair follicle
- thymus
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - nucleotide binding
- DNA binding
- telomeric DNA binding
- helicase activity
- DNA helicase activity
- single-stranded DNA helicase activity
- 5'-3' DNA/RNA helicase activity
- hydrolase activity
- ATP binding
- magnesium ion binding
- telomerase inhibitor activity
- 5'-3' DNA helicase activity
- G-quadruplex DNA binding
| Cellular component | - replication fork
- mitochondrion
- nucleus
| Biological process | - DNA recombination
- regulation of telomere maintenance
- negative regulation of telomerase activity
- G-quadruplex DNA unwinding
- cellular response to DNA damage stimulus
- telomere maintenance
- DNA repair
- DNA duplex unwinding
- mitochondrial genome maintenance
- DNA replication
- negative regulation of telomere maintenance via telomerase
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001286496 NM_001286497 NM_001286499 NM_025049 |
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NM_172453 NM_001357526 NM_001357527 |
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RefSeq (protein) | |
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NP_001273425 NP_001273426 NP_001273428 NP_079325 |
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NP_766041 NP_001344455 NP_001344456 |
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Location (UCSC) | Chr 15: 64.82 – 64.83 Mb | Chr 9: 65.59 – 65.6 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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