Protein-coding gene in the species Homo sapiens
PHF7 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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Identifiers |
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Aliases | PHF7, HSPC045, HSPC226, NYD-SP6, PHD finger protein 7 |
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External IDs | MGI: 1919088; HomoloGene: 69217; GeneCards: PHF7; OMA:PHF7 - orthologs |
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Gene location (Human) |
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![Chromosome 3 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/3/39/Ideogram_human_chromosome_3.svg/300px-Ideogram_human_chromosome_3.svg.png) | Chr. | Chromosome 3 (human)[1] |
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| Band | 3p21.1 | Start | 52,410,660 bp[1] |
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End | 52,423,641 bp[1] |
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Gene location (Mouse) |
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![Chromosome 14 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/e/e5/Ideogram_house_mouse_chromosome_14.svg/260px-Ideogram_house_mouse_chromosome_14.svg.png) | Chr. | Chromosome 14 (mouse)[2] |
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| Band | 14|14 B | Start | 30,959,646 bp[2] |
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End | 30,973,274 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - right testis
- left testis
- sperm
- testicle
- sural nerve
- Achilles tendon
- rectum
- transverse colon
- gastric mucosa
- skin of leg
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| Top expressed in | - seminiferous tubule
- spermatid
- spermatocyte
- Paneth cell
- primary oocyte
- internal carotid artery
- fossa
- external carotid artery
- corneal stroma
- zygote
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| More reference expression data |
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BioGPS | |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001278221 NM_016483 NM_173341 NM_001321126 NM_001321127 |
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NM_027949 NM_001360624 NM_001360625 |
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RefSeq (protein) | |
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NP_001265150 NP_001308055 NP_001308056 NP_057567 |
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NP_082225 NP_001347553 NP_001347554 |
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Location (UCSC) | Chr 3: 52.41 – 52.42 Mb | Chr 14: 30.96 – 30.97 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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PHD finger protein 7 is a protein that in humans is encoded by the PHF7 gene. [5]
Function
Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells.
The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000010318 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021902 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: PHD finger protein 7". Retrieved 2017-09-05.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.