PHD finger protein 7

Protein-coding gene in the species Homo sapiens
PHF7
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WEQ

Identifiers
AliasesPHF7, HSPC045, HSPC226, NYD-SP6, PHD finger protein 7
External IDsMGI: 1919088; HomoloGene: 69217; GeneCards: PHF7; OMA:PHF7 - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for PHF7
Genomic location for PHF7
Band3p21.1Start52,410,660 bp[1]
End52,423,641 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for PHF7
Genomic location for PHF7
Band14|14 BStart30,959,646 bp[2]
End30,973,274 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • sperm

  • testicle

  • sural nerve

  • Achilles tendon

  • rectum

  • transverse colon

  • gastric mucosa

  • skin of leg
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • Paneth cell

  • primary oocyte

  • internal carotid artery

  • fossa

  • external carotid artery

  • corneal stroma

  • zygote
More reference expression data
BioGPS
n/a
Orthologs
SpeciesHumanMouse
Entrez

51533

71838

Ensembl

ENSG00000010318

ENSMUSG00000021902

UniProt

Q9BWX1

Q9DAG9

RefSeq (mRNA)

NM_001278221
NM_016483
NM_173341
NM_001321126
NM_001321127

NM_027949
NM_001360624
NM_001360625

RefSeq (protein)

NP_001265150
NP_001308055
NP_001308056
NP_057567

NP_082225
NP_001347553
NP_001347554

Location (UCSC)Chr 3: 52.41 – 52.42 MbChr 14: 30.96 – 30.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

PHD finger protein 7 is a protein that in humans is encoded by the PHF7 gene. [5]

Function

Spermatogenesis is a complex process regulated by extracellular and intracellular factors as well as cellular interactions among interstitial cells of the testis, Sertoli cells, and germ cells. This gene is expressed in the testis in Sertoli cells but not germ cells.

The protein encoded by this gene contains plant homeodomain (PHD) finger domains, also known as leukemia associated protein (LAP) domains, believed to be involved in transcriptional regulation. The protein, which localizes to the nucleus of transfected cells, has been implicated in the transcriptional regulation of spermatogenesis. Alternate splicing results in multiple transcript variants of this gene.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000010318 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021902 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PHD finger protein 7". Retrieved 2017-09-05.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e