OTUD7B

Protein-coding gene in the species Homo sapiens
OTUD7B
Identifiers
AliasesOTUD7B, CEZANNE, ZA20D1, OTU deubiquitinase 7B
External IDsOMIM: 611748; MGI: 2654703; HomoloGene: 10624; GeneCards: OTUD7B; OMA:OTUD7B - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for OTUD7B
Genomic location for OTUD7B
Band1q21.2Start149,937,812 bp[1]
End150,010,726 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for OTUD7B
Genomic location for OTUD7B
Band3|3 F2.1Start96,011,839 bp[2]
End96,068,446 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • internal globus pallidus

  • sural nerve

  • secondary oocyte

  • tendon of biceps brachii

  • corpus callosum

  • inferior ganglion of vagus nerve

  • C1 segment

  • Skeletal muscle tissue of biceps brachii

  • epithelium of colon
Top expressed in
  • blood

  • retinal pigment epithelium

  • sciatic nerve

  • right lung lobe

  • neural layer of retina

  • spermatid

  • lumbar subsegment of spinal cord

  • spermatocyte

  • triceps brachii muscle

  • muscle of thigh
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • cysteine-type peptidase activity
  • zinc ion binding
  • metal ion binding
  • peptidase activity
  • K63-linked polyubiquitin modification-dependent protein binding
  • protein binding
  • thiol-dependent deubiquitinase
  • hydrolase activity
  • Lys48-specific deubiquitinase activity
Cellular component
  • cytoplasm
  • nucleus
  • cytosol
Biological process
  • mucosal immune response
  • negative regulation of protein localization to nucleus
  • protein K48-linked deubiquitination
  • protein deubiquitination involved in ubiquitin-dependent protein catabolic process
  • immune system process
  • negative regulation of transcription by RNA polymerase II
  • negative regulation of I-kappaB kinase/NF-kappaB signaling
  • proteolysis
  • negative regulation of interleukin-8 production
  • protein K63-linked deubiquitination
  • immune response
  • protein deubiquitination
  • protein K11-linked deubiquitination
  • adaptive immune response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56957

229603

Ensembl

ENSG00000264522

ENSMUSG00000038495

UniProt

Q6GQQ9

B2RUR8

RefSeq (mRNA)

NM_020205

NM_001025613
NM_001025614

RefSeq (protein)

NP_064590

NP_001020784
NP_001020785

Location (UCSC)Chr 1: 149.94 – 150.01 MbChr 3: 96.01 – 96.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

OTU domain-containing protein 7B is a protein that in humans is encoded by the OTUD7B gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000264522 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038495 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (Jul 2001). "Isolation and characterization of two novel A20-like proteins". Biochemical Journal. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.
  6. ^ "Entrez Gene: OTUD7B OTU domain containing 7B".

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Evans PC, Ovaa H, Hamon M, et al. (2004). "Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity". Biochem. J. 378 (Pt 3): 727–34. doi:10.1042/BJ20031377. PMC 1224040. PMID 14748687.
  • Evans PC, Smith TS, Lai MJ, et al. (2003). "A novel type of deubiquitinating enzyme". Journal of Biological Chemistry. 278 (25): 23180–6. doi:10.1074/jbc.M301863200. PMID 12682062.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Letters. 442 (2–3): 147–50. doi:10.1016/S0014-5793(98)01645-7. PMID 9928991.


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