OTUD7B |
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Identifiers |
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Aliases | OTUD7B, CEZANNE, ZA20D1, OTU deubiquitinase 7B |
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External IDs | OMIM: 611748; MGI: 2654703; HomoloGene: 10624; GeneCards: OTUD7B; OMA:OTUD7B - orthologs |
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Gene location (Human) |
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![Chromosome 1 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png) | Chr. | Chromosome 1 (human)[1] |
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| Band | 1q21.2 | Start | 149,937,812 bp[1] |
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End | 150,010,726 bp[1] |
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Gene location (Mouse) |
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![Chromosome 3 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/0/08/Ideogram_house_mouse_chromosome_3.svg/260px-Ideogram_house_mouse_chromosome_3.svg.png) | Chr. | Chromosome 3 (mouse)[2] |
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| Band | 3|3 F2.1 | Start | 96,011,839 bp[2] |
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End | 96,068,446 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - buccal mucosa cell
- internal globus pallidus
- sural nerve
- secondary oocyte
- tendon of biceps brachii
- corpus callosum
- inferior ganglion of vagus nerve
- C1 segment
- Skeletal muscle tissue of biceps brachii
- epithelium of colon
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| Top expressed in | - blood
- retinal pigment epithelium
- sciatic nerve
- right lung lobe
- neural layer of retina
- spermatid
- lumbar subsegment of spinal cord
- spermatocyte
- triceps brachii muscle
- muscle of thigh
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/9/96/PBB_GE_OTUD7B_220031_at_fs.png/250px-PBB_GE_OTUD7B_220031_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - DNA binding
- cysteine-type peptidase activity
- zinc ion binding
- metal ion binding
- peptidase activity
- K63-linked polyubiquitin modification-dependent protein binding
- protein binding
- thiol-dependent deubiquitinase
- hydrolase activity
- Lys48-specific deubiquitinase activity
| Cellular component | - cytoplasm
- nucleus
- cytosol
| Biological process | - mucosal immune response
- negative regulation of protein localization to nucleus
- protein K48-linked deubiquitination
- protein deubiquitination involved in ubiquitin-dependent protein catabolic process
- immune system process
- negative regulation of transcription by RNA polymerase II
- negative regulation of I-kappaB kinase/NF-kappaB signaling
- proteolysis
- negative regulation of interleukin-8 production
- protein K63-linked deubiquitination
- immune response
- protein deubiquitination
- protein K11-linked deubiquitination
- adaptive immune response
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 149.94 – 150.01 Mb | Chr 3: 96.01 – 96.07 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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