NOMO1

Protein-coding gene in the species Homo sapiens
NOMO1
Identifiers
AliasesNOMO1, Nomo, PM5, NODAL modulator 1
External IDsOMIM: 609157; MGI: 2385850; HomoloGene: 13810; GeneCards: NOMO1; OMA:NOMO1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for NOMO1
Genomic location for NOMO1
Band16p13.11Start14,833,721 bp[1]
End14,896,157 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for NOMO1
Genomic location for NOMO1
Band7 B3|7 29.66 cMStart45,683,122 bp[2]
End45,733,636 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • islet of Langerhans

  • superior frontal gyrus

  • body of pancreas

  • primary visual cortex

  • stromal cell of endometrium

  • corpus callosum

  • nucleus accumbens

  • right auricle

  • Brodmann area 9

  • Achilles tendon
Top expressed in
  • otic placode

  • saccule

  • entorhinal cortex

  • perirhinal cortex

  • Ileal epithelium

  • crypt of lieberkuhn of small intestine

  • lactiferous gland

  • choroid plexus of fourth ventricle

  • CA3 field

  • otic vesicle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • carbohydrate binding
  • molecular function
Cellular component
  • membrane
  • integral component of membrane
  • endoplasmic reticulum membrane
Biological process
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23420

211548

Ensembl

ENSG00000103512

ENSMUSG00000030835

UniProt

Q15155

Q6GQT9

RefSeq (mRNA)

NM_014287

NM_153057

RefSeq (protein)

NP_055102

NP_694697

Location (UCSC)Chr 16: 14.83 – 14.9 MbChr 7: 45.68 – 45.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nodal modulator 1 is a protein that in humans is encoded by the NOMO1 gene.[5][6][7]

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE).[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103512 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030835 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Templeton NS, Rodgers LA, Levy AT, Ting KL, Krutzsch HC, Liotta LA, Stetler-Stevenson WG (Mar 1992). "Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family". Genomics. 12 (1): 175–6. doi:10.1016/0888-7543(92)90425-R. PMID 1310294.
  6. ^ Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C (Aug 2004). "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists". EMBO J. 23 (15): 3041–50. doi:10.1038/sj.emboj.7600307. PMC 514924. PMID 15257293.
  7. ^ a b "Entrez Gene: NOMO1 NODAL modulator 1".

Further reading

  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
  • Martin J, Han C, Gordon LA, et al. (2005). "The sequence and analysis of duplication-rich human chromosome 16". Nature. 432 (7020): 988–94. Bibcode:2004Natur.432..988M. doi:10.1038/nature03187. PMID 15616553.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Loftus BJ, Kim UJ, Sneddon VP, et al. (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
  • van Soest S, Swart J, Tijmes N, et al. (1997). "A Locus for Autosomal Recessive Pseudoxanthoma Elasticum, with Penetrance of Vascular Symptoms in Carriers, Maps to Chromosome 16p13.1". Genome Res. 7 (8): 830–4. doi:10.1101/gr.7.8.830. PMC 310666. PMID 9267806.
  • Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.


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