NDRG4

Protein-coding gene in the species Homo sapiens
NDRG4
Identifiers
AliasesNDRG4, BDM1, SMAP-8, SMAP8, NDRG family member 4
External IDsOMIM: 614463; MGI: 2384590; HomoloGene: 23228; GeneCards: NDRG4; OMA:NDRG4 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for NDRG4
Genomic location for NDRG4
Band16q21Start58,462,846 bp[1]
End58,513,628 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for NDRG4
Genomic location for NDRG4
Band8|8 D1Start95,676,980 bp[2]
End95,715,119 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • pons

  • lateral nuclear group of thalamus

  • right frontal lobe

  • prefrontal cortex

  • apex of heart

  • nucleus accumbens

  • cerebellar vermis

  • caudate nucleus

  • dorsolateral prefrontal cortex
Top expressed in
  • olfactory tubercle

  • medial dorsal nucleus

  • medial geniculate nucleus

  • pontine nuclei

  • dorsal tegmental nucleus

  • habenula

  • medial vestibular nucleus

  • lateral geniculate nucleus

  • nucleus accumbens

  • globus pallidus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • molecular function
Cellular component
  • cytosol
  • basolateral plasma membrane
  • cell projection membrane
  • cytoplasm
  • mitochondrion
  • endoplasmic reticulum membrane
Biological process
  • visual learning
  • negative regulation of platelet-derived growth factor receptor signaling pathway
  • cell migration involved in heart development
  • cell differentiation
  • negative regulation of smooth muscle cell proliferation
  • regulation of endocytic recycling
  • negative regulation of smooth muscle cell migration
  • cardiac muscle cell proliferation
  • embryonic heart tube development
  • heart looping
  • cell growth
  • vesicle docking
  • positive regulation of ERK1 and ERK2 cascade
  • positive regulation of neuron projection development
  • brain development
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

65009

234593

Ensembl

ENSG00000103034

ENSMUSG00000036564

UniProt

Q9ULP0

Q8BTG7

RefSeq (mRNA)
NM_001130487
NM_001242833
NM_001242834
NM_001242835
NM_001242836

NM_020465
NM_022910
NM_001363869

NM_001195006
NM_145602

RefSeq (protein)
NP_001123959
NP_001229762
NP_001229763
NP_001229764
NP_001229765

NP_065198
NP_075061
NP_001350798
NP_001365261
NP_001365262
NP_001365263
NP_001365264
NP_001365265
NP_001365266
NP_001365267
NP_001365268
NP_001365269
NP_001365270
NP_001365271
NP_001365272
NP_001365273
NP_001365274
NP_001365275
NP_001365276

NP_001181935
NP_663577
NP_001359350
NP_001359352
NP_001359354

NP_001359355
NP_001359356
NP_001359357
NP_001359358
NP_001359359
NP_001359360
NP_001359361
NP_001359362
NP_001359363
NP_001359364

Location (UCSC)Chr 16: 58.46 – 58.51 MbChr 8: 95.68 – 95.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein NDRG4 is a protein that in humans is encoded by the NDRG4 gene.[5][6][7]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103034 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036564 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhou RH, Kokame K, Tsukamoto Y, Yutani C, Kato H, Miyata T (May 2001). "Characterization of the human NDRG gene family: a newly identified member, NDRG4, is specifically expressed in brain and heart". Genomics. 73 (1): 86–97. doi:10.1006/geno.2000.6496. PMID 11352569.
  6. ^ Hongo S, Watanabe T, Takahashi K, Miyazaki A (Apr 2006). "Ndrg4 enhances NGF-induced ERK activation uncoupled with Elk-1 activation". J Cell Biochem. 98 (1): 185–93. doi:10.1002/jcb.20763. PMID 16408304. S2CID 10192022.
  7. ^ a b "Entrez Gene: NDRG4 NDRG family member 4".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Qu X, Zhai Y, Wei H, et al. (2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol. Cell. Biochem. 229 (1–2): 35–44. doi:10.1023/A:1017934810825. PMID 11936845. S2CID 24226208.
  • Ohki T, Hongo S, Nakada N, et al. (2002). "Inhibition of neurite outgrowth by reduced level of NDRG4 protein in antisense transfected PC12 cells". Brain Res. Dev. Brain Res. 135 (1–2): 55–63. doi:10.1016/S0165-3806(02)00300-0. PMID 11978393.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Nishimoto S, Tawara J, Toyoda H, et al. (2003). "A novel homocysteine-responsive gene, smap8, modulates mitogenesis in rat vascular smooth muscle cells". Eur. J. Biochem. 270 (11): 2521–31. doi:10.1046/j.1432-1033.2003.03626.x. PMID 12755708.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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