NDC1

Protein-coding gene in the species Homo sapiens
NDC1
Identifiers
AliasesNDC1, NET3, TMEM48, NDC1 transmembrane nucleoporin
External IDsOMIM: 610115; MGI: 1920037; HomoloGene: 41224; GeneCards: NDC1; OMA:NDC1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for NDC1
Genomic location for NDC1
Band1p32.3Start53,765,478 bp[1]
End53,838,463 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for NDC1
Genomic location for NDC1
Band4|4 C7Start107,224,981 bp[2]
End107,273,543 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • gonad

  • ventricular zone

  • tibia

  • gingival epithelium

  • epithelium of nasopharynx

  • mucosa of colon

  • mucosa of sigmoid colon

  • germinal epithelium

  • testicle
Top expressed in
  • tail of embryo

  • genital tubercle

  • primitive streak

  • cumulus cell

  • spermatocyte

  • epiblast

  • maxillary prominence

  • condyle

  • yolk sac

  • medullary collecting duct
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • structural constituent of nuclear pore
Cellular component
  • cytoplasm
  • integral component of membrane
  • nuclear membrane
  • nuclear envelope
  • membrane
  • plasma membrane
  • nuclear pore
  • actin cytoskeleton
  • nucleus
  • spindle pole body
  • nuclear pore transmembrane ring
  • host cell
Biological process
  • mRNA transport
  • nuclear pore complex assembly
  • viral transcription
  • protein sumoylation
  • mitotic nuclear membrane disassembly
  • homologous chromosome pairing at meiosis
  • spermatogenesis
  • protein transport
  • regulation of cellular response to heat
  • viral process
  • mRNA export from nucleus
  • intracellular transport of virus
  • tRNA export from nucleus
  • spindle pole body duplication
  • regulation of gene silencing by miRNA
  • regulation of glycolytic process
  • transport
  • nuclear pore organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55706

72787

Ensembl

ENSG00000058804

ENSMUSG00000028614

UniProt

Q9BTX1

Q8VCB1

RefSeq (mRNA)

NM_001168551
NM_018087

NM_028355

RefSeq (protein)

NP_001162023
NP_060557

NP_082631

Location (UCSC)Chr 1: 53.77 – 53.84 MbChr 4: 107.22 – 107.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin NDC1 is a protein that in humans is encoded by the TMEM48 gene.[5][6][7] It anchors aladin to the nuclear pore complex.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000058804 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028614 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lau CK, Delmar VA, Forbes DJ (Aug 2006). "Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue". Anat Rec A. 288 (7): 681–94. doi:10.1002/ar.a.20335. PMC 3049984. PMID 16779818.
  6. ^ Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L (Sep 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID 12958361. S2CID 23832536.
  7. ^ "Entrez Gene: TMEM48 transmembrane protein 48".
  8. ^ Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (December 2009). "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope". Biochemical and Biophysical Research Communications. 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080. PMID 19782045.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Mansfeld J, Güttinger S, Hawryluk-Gara LA, et al. (2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells". Mol. Cell. 22 (1): 93–103. doi:10.1016/j.molcel.2006.02.015. PMID 16600873.
  • Stavru F, Hülsmann BB, Spang A, et al. (2006). "NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes" (PDF). J. Cell Biol. 173 (4): 509–19. doi:10.1083/jcb.200601001. PMC 2063861. PMID 16702233.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.


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