NCLN

Protein-coding gene in the species Homo sapiens
NCLN
Identifiers
AliasesNCLN, NET59, nicalin
External IDsOMIM: 609156; MGI: 1926081; HomoloGene: 10604; GeneCards: NCLN; OMA:NCLN - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for NCLN
Genomic location for NCLN
Band19p13.3Start3,185,563 bp[1]
End3,209,575 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for NCLN
Genomic location for NCLN
Band10|10 C1Start81,322,083 bp[2]
End81,332,226 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • stromal cell of endometrium

  • left adrenal gland

  • right adrenal gland

  • left adrenal cortex

  • right adrenal cortex

  • body of pancreas

  • right lobe of liver

  • granulocyte

  • right hemisphere of cerebellum
Top expressed in
  • granulocyte

  • right kidney

  • interventricular septum

  • lip

  • spermatocyte

  • muscle of thigh

  • yolk sac

  • tail of embryo

  • ventricular zone

  • neural layer of retina
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • integral component of membrane
  • endoplasmic reticulum membrane
  • membrane
  • endoplasmic reticulum
  • protein-containing complex
Biological process
  • regulation of protein-containing complex assembly
  • protein destabilization
  • regulation of signal transduction
  • protein stabilization
  • regulation of protein complex stability
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56926

103425

Ensembl

ENSG00000125912

ENSMUSG00000020238

UniProt

Q969V3

Q8VCM8

RefSeq (mRNA)

NM_020170
NM_001321463

NM_134009

RefSeq (protein)

NP_001308392
NP_064555

NP_598770

Location (UCSC)Chr 19: 3.19 – 3.21 MbChr 10: 81.32 – 81.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nicalin is a protein that in humans is encoded by the NCLN gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000125912 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020238 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ "Entrez Gene: NCLN nicalin homolog (zebrafish)".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
  • Haffner C, Frauli M, Topp S, et al. (2005). "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists". EMBO J. 23 (15): 3041–50. doi:10.1038/sj.emboj.7600307. PMC 514924. PMID 15257293.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.


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