NCAPD3

Protein-coding gene in the species Homo sapiens
NCAPD3
Identifiers
AliasesNCAPD3, CAP-D3, CAPD3, hCAP-D3, hHCP-6, hcp-6, non-SMC condensin II complex subunit D3, MCPH22
External IDsOMIM: 609276; MGI: 2142989; HomoloGene: 41021; GeneCards: NCAPD3; OMA:NCAPD3 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NCAPD3
Genomic location for NCAPD3
Band11q25Start134,150,113 bp[1]
End134,225,504 bp[1]
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)[2]
Chromosome 9 (mouse)
Genomic location for NCAPD3
Genomic location for NCAPD3
Band9|9 A4Start26,941,471 bp[2]
End27,006,611 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • secondary oocyte

  • ventricular zone

  • gonad

  • prostate

  • ganglionic eminence

  • testicle

  • stromal cell of endometrium

  • right lobe of liver

  • left testis
Top expressed in
  • hand

  • Gonadal ridge

  • Paneth cell

  • primary oocyte

  • thymus

  • dermis

  • human fetus

  • superior cervical ganglion

  • neural layer of retina

  • abdominal wall
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • methylated histone binding
  • chromatin binding
  • protein binding
  • histone binding
Cellular component
  • membrane
  • nucleus
  • condensed chromosome, centromeric region
  • nucleoplasm
Biological process
  • mitotic chromosome condensation
  • chromosome separation
  • cell division
  • cell cycle
  • chromosome condensation
  • meiotic chromosome condensation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23310

78658

Ensembl

ENSG00000151503

ENSMUSG00000035024

UniProt

P42695

Q6ZQK0

RefSeq (mRNA)

NM_015261
NM_001372065
NM_001372068
NM_001372069
NM_001372070

NM_178113
NM_001382847

RefSeq (protein)

NP_056076
NP_001358994
NP_001358997
NP_001358998
NP_001358999

NP_835214
NP_001369776

Location (UCSC)Chr 11: 134.15 – 134.23 MbChr 9: 26.94 – 27.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Condensin-2 complex subunit D3 (CAP-D3) also known as non-SMC condensin II complex subunit D3 (NCAPD3) is a protein that, in humans, is encoded by the NCAPD3 gene.[5][6][7][8] CAP-D3 is a subunit of condensin II, a large protein complex involved in chromosome condensation.

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151503 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035024 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (December 1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–229. doi:10.1093/dnares/1.5.223. PMID 7584044.
  6. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (June 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–113. doi:10.1006/abio.1996.0138. PMID 8619474.
  7. ^ Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T (October 2003). "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells". Cell. 115 (1): 109–121. doi:10.1016/S0092-8674(03)00724-4. PMID 14532007. S2CID 18811084.
  8. ^ "NCAPD3 non-SMC condensin II complex, subunit D3". National Center for Biotechnology Information. Retrieved June 10, 2012.

Further reading

  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.


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