MT1X

Protein-coding gene in the species Homo sapiens
MT1X
Identifiers
AliasesMT1X, MT-1l, MT1, metallothionein 1X
External IDsOMIM: 156359; HomoloGene: 130542; GeneCards: MT1X; OMA:MT1X - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for MT1X
Genomic location for MT1X
Band16q13Start56,682,470 bp[1]
End56,684,196 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • pericardium

  • right lobe of liver

  • gastrocnemius muscle

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • skin of abdomen

  • muscle of thigh

  • skin of leg

  • tibialis anterior muscle

  • external globus pallidus
    n/a
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
  • metal ion binding
  • zinc ion binding
  • copper ion binding
Cellular component
  • cytoplasm
  • perinuclear region of cytoplasm
  • nucleus
  • lysosome
  • cytosol
Biological process
  • response to metal ion
  • cellular response to erythropoietin
  • negative regulation of growth
  • cellular response to cadmium ion
  • cellular response to zinc ion
  • cellular metal ion homeostasis
  • cellular zinc ion homeostasis
  • nitric oxide mediated signal transduction
  • detoxification of copper ion
  • negative regulation of neuron apoptotic process
  • cellular response to chromate
  • cellular response to copper ion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4501

n/a

Ensembl

ENSG00000187193

n/a

UniProt

P80297

n/a

RefSeq (mRNA)

NM_005952

n/a

RefSeq (protein)

NP_005943

n/a

Location (UCSC)Chr 16: 56.68 – 56.68 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Metallothionein 1X, also known as MT1X, is a protein which in humans is encoded by the gene.[3][4][5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187193 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: MT1X metallothionein 1X".
  4. ^ West AK, Stallings R, Hildebrand CE, Chiu R, Karin M, Richards RI (November 1990). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
  5. ^ Stennard FA, Holloway AF, Hamilton J, West AK (August 1994). "Characterisation of six additional human metallothionein genes". Biochim. Biophys. Acta. 1218 (3): 357–65. doi:10.1016/0167-4781(94)90189-9. PMID 8049263.

Further reading

  • West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
  • Stennard FA, Holloway AF, Hamilton J, West AK (1994). "Characterisation of six additional human metallothionein genes". Biochim. Biophys. Acta. 1218 (3): 357–65. doi:10.1016/0167-4781(94)90189-9. PMID 8049263.
  • Pauwels M, van Weyenbergh J, Soumillion A, et al. (1994). "Induction by zinc of specific metallothionein isoforms in human monocytes". Eur. J. Biochem. 220 (1): 105–10. doi:10.1111/j.1432-1033.1994.tb18603.x. PMID 8119276.
  • Mididoddi S, McGuirt JP, Sens MA, et al. (1996). "Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney". Toxicol. Lett. 85 (1): 17–27. doi:10.1016/0378-4274(96)03632-6. PMID 8619255.
  • Holloway AF, Stennard FA, West AK (1997). "Human metallothionein gene MT1L mRNA is present in several human tissues but is unlikely to produce a metallothionein protein". FEBS Lett. 404 (1): 41–4. doi:10.1016/S0014-5793(97)00082-3. PMID 9074634. S2CID 46527743.
  • Garrett SH, Somji S, Todd JH, et al. (1999). "Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals". Environ. Health Perspect. 106 (12): 825–32. doi:10.2307/3434126. JSTOR 3434126. PMC 1533231. PMID 9831543.
  • Hellemans G, Soumillion A, Proost P, et al. (2000). "Metallothioneins in human kidneys and associated tumors". Nephron. 83 (4): 331–40. doi:10.1159/000045425. PMID 10575295. S2CID 26103380.
  • Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer". Prostate. 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528. S2CID 8768274.
  • Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes". Cell. Mol. Biol. (Noisy-le-grand). 46 (2): 419–33. PMID 10774930.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood". Eur. J. Biochem. 268 (3): 849–56. doi:10.1046/j.1432-1327.2001.01947.x. PMID 11168427.
  • Garrett SH, Belcastro M, Sens MA, et al. (2001). "Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells". J. Toxicol. Environ. Health A. 64 (4): 343–55. Bibcode:2001JTEHA..64..343G. doi:10.1080/152873901316981321. PMID 11693492. S2CID 43143430.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
  • Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
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