MIR194-1 : Function, Further reading Wikipedia, the free encyclopedia

MIR194-1

Non-coding RNA in the species Homo sapiens

MIR194-1

Identifiers

Aliases

MIR194-1, MIRN194-1, mir-194-1, microRNA 194-1

External IDs

OMIM: 610940; GeneCards: MIR194-1; OMA:MIR194-1 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q41	Start	220,118,157 bp^[1]
Band	1q41	End	220,118,241 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

amygdala

Achilles tendon

kidney

duodenum

endometrium

lymph node

blood

monocyte

gastrocnemius muscle

human kidney

n/a

More reference expression data

BioGPS

n/a

Orthologs

Species

Human

Mouse

Entrez


406969


n/a

Ensembl


ENSG00000207624


n/a

UniProt


n a


n/a

RefSeq (mRNA)


n/a


n/a

RefSeq (protein)


n/a


n/a

Location (UCSC)

Chr 1: 220.12 – 220.12 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene.^[3]

Function

microRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.^[3]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000207624 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MicroRNA 194-1". Retrieved 2014-05-29.

Sundaram P, Hultine S, Smith LM, Dews M, Fox JL, Biyashev D, Schelter JM, Huang Q, Cleary MA, Volpert OV, Thomas-Tikhonenko A (Dec 2011). "p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers". Cancer Research. 71 (24): 7490–7501. doi:10.1158/0008-5472.CAN-11-1124. PMC 3242824. PMID 22028325.
Dong P, Kaneuchi M, Watari H, Hamada J, Sudo S, Ju J, Sakuragi N (2011). "MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1". Molecular Cancer. 10: 99. doi:10.1186/1476-4598-10-99. PMC 3173388. PMID 21851624.
Song Y, Zhao F, Wang Z, Liu Z, Chiang Y, Xu Y, Gao P, Xu H (Jul 2012). "Inverse association between miR-194 expression and tumor invasion in gastric cancer". Annals of Surgical Oncology. 19 (Suppl 3): S509–17. doi:10.1245/s10434-011-1999-2. PMID 21845495. S2CID 6856251.
Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (Feb 2003). "New microRNAs from mouse and human". RNA. 9 (2): 175–179. doi:10.1261/rna.2146903. PMC 1370382. PMID 12554859.
Xu J, Kang Y, Liao WM, Yu L (2012). "MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5". PLOS ONE. 7 (3): e31861. Bibcode:2012PLoSO...731861X. doi:10.1371/journal.pone.0031861. PMC 3291608. PMID 22396742.
Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin HJ, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM (Oct 2010). "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development". Cancer Cell. 18 (4): 367–381. doi:10.1016/j.ccr.2010.09.005. PMC 3561766. PMID 20951946.
Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ (Oct 2003). "Reduced accumulation of specific microRNAs in colorectal neoplasia". Molecular Cancer Research. 1 (12): 882–891. PMID 14573789.