LOC642658

SCX
Identifiers
Aliases	SCX, SCXA, SCXB, bHLHa48, LOC642658, scleraxis bHLH transcription factor
External IDs	OMIM: 609067; MGI: 102934; HomoloGene: 85195; GeneCards: SCX; OMA:SCX - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,266,453 bp[1] End 144,268,481 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 D3|15 35.92 cM Start 76,341,652 bp[2] End 76,343,658 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus quadriceps femoris muscle right lobe of thyroid gland left lobe of thyroid gland Achilles tendon right hemisphere of cerebellum anterior pituitary muscle of thigh gonad ascending aorta Top expressed in digit toe metatarsal bones fifth metatarsal bone interventricular septum plantaris muscle cardiac muscle tissue of left ventricle fourth metatarsal bone extensor digitorum longus muscle finger More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding protein dimerization activity bHLH transcription factor binding E-box binding DNA-binding transcription activator activity, RNA polymerase II-specific protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus Biological process cellular response to transforming growth factor beta stimulus positive regulation of collagen biosynthetic process cell differentiation regulation of transcription, DNA-templated chondrocyte differentiation regulation of cartilage development positive regulation of gastrulation collagen fibril organization tendon development tendon cell differentiation mesoderm formation cellular response to BMP stimulus negative regulation of apoptotic process Sertoli cell differentiation endochondral ossification transcription by RNA polymerase II BMP signaling pathway transcription, DNA-templated sclerotome development embryonic skeletal system development positive regulation of transcription, DNA-templated multicellular organism development deltoid tuberosity development cellular response to mechanical stimulus positive regulation of gene expression heart valve formation positive regulation of cartilage development heart valve morphogenesis tissue homeostasis positive regulation of cell population proliferation tendon formation skeletal muscle cell differentiation negative regulation of transcription, DNA-templated face morphogenesis positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 642658 20289 Ensembl ENSG00000260428 ENSMUSG00000034161 UniProt Q7RTU7 Q64124 RefSeq (mRNA) NM_001008271 NM_001080514 NM_198885 RefSeq (protein) NP_001073983 NP_942588 Location (UCSC) Chr 8: 144.27 – 144.27 Mb Chr 15: 76.34 – 76.34 Mb PubMed search [3] [4]
Wikidata
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Basic helix-loop-helix transcription factor scleraxis is a protein that in humans is encoded by the SCXB gene.^[5]

References